Gene: EZH1
Official Full Name: enhancer of zeste 1 polycomb repressive complex 2 subunitprovided by HGNC
Gene Summary: EZH1 is a component of a noncanonical Polycomb repressive complex-2 (PRC2) that mediates methylation of histone H3 (see MIM 602812) lys27 (H3K27) and functions in the maintenance of embryonic stem cell pluripotency and plasticity (Shen et al., 2008 [PubMed 19026780]).[supplied by OMIM, Mar 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO04052 | EZH1 Knockout cell line (HeLa) | Human | EZH1 | 1:3~1:6 | Negative | Online Inquiry |
KO04053 | EZH1 Knockout cell line (HCT 116) | Human | EZH1 | 1:2~1:4 | Negative | Online Inquiry |
KO04054 | EZH1 Knockout cell line (HEK293) | Human | EZH1 | 1:3~1:6 | Negative | Online Inquiry |
KO04055 | EZH1 Knockout cell line (A549) | Human | EZH1 | 1:3~1:4 | Negative | Online Inquiry |
EZH1 Gene Knockout Cell Lines represent a cutting-edge tool in molecular biology, specifically designed for the study of gene function and regulation. These cell lines have been meticulously engineered using CRISPR-Cas9 technology to disrupt the EZH1 gene, a critical component of the Polycomb-repressive complex 2 (PRC2), which is pivotal for regulating gene expression during development and cellular differentiation. By utilizing these knockout models, researchers can investigate the roles of EZH1 in various biological processes, including stem cell biology, cancer progression, and epigenetic regulation.
The key function of EZH1 Gene Knockout Cell Lines lies in their ability to facilitate the assessment of gene function by providing unambiguous evidence of EZH1's contribution to different cellular phenotypes. The effective knockout of this gene allows for the exploration of downstream targets and pathways, revealing insights into how aberrations in epigenetic regulation may lead to disease states. These cell lines serve as invaluable resources for both basic and applied research in academic and clinical settings, contributing to advances in cancer therapeutics, regenerative medicine, and the understanding of developmental biology.
One of the significant advantages of using EZH1 Gene Knockout Cell Lines is their high specificity and reproducibility compared to conventional methods of gene knockdown such as RNA interference. The precise, irreversible alterations in the genomic sequence provided by CRISPR technology allow for definitive conclusions regarding gene function, thereby enhancing the validity of experimental outcomes. Additionally, these cell lines are readily accessible and compatible with various high-throughput screening systems, making them ideal for large-scale investigations.
For researchers and clinicians focused on uncovering the mechanistic underpinnings of diseases or seeking to develop novel therapeutics, EZH1 Gene Knockout Cell Lines present an invaluable asset. They enable a detailed analysis of the implications of EZH1 loss on cellular behaviors, thus opening new avenues for targeted therapies.
With a robust background in molecular biology and genetic engineering, our company is positioned as a leader in the development of innovative biological products. We are committed to providing high-quality tools, such as the EZH1 Gene Knockout Cell Lines, that empower researchers and drive forward the frontiers of biomedical research.
Please note that all services are for research use only. Not intended for any clinical use.
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