Gene: EXD2
Official Full Name: exonuclease 3'-5' domain containing 2provided by HGNC
Gene Summary: Enables 3'-5' exonuclease activity; metal ion binding activity; and protein homodimerization activity. Involved in DNA double-strand break processing; double-strand break repair via homologous recombination; and replication fork processing. Located in intermediate filament cytoskeleton; mitochondrial outer membrane; and site of DNA damage. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO17862 | EXD2 Knockout cell line (HeLa) | Human | EXD2 | 1:3~1:6 | Negative | Online Inquiry |
KO17863 | EXD2 Knockout cell line (HCT 116) | Human | EXD2 | 1:2~1:4 | Negative | Online Inquiry |
KO17864 | EXD2 Knockout cell line (HEK293) | Human | EXD2 | 1:3~1:6 | Negative | Online Inquiry |
KO17865 | EXD2 Knockout cell line (A549) | Human | EXD2 | 1:3~1:4 | Negative | Online Inquiry |
EXD2 Gene Knockout Cell Lines are a cutting-edge biological research tool designed to facilitate the study of the EXD2 gene and its associated pathways in cellular processes. These knockout cell lines are engineered to ablate the EXD2 gene, effectively elucidating its role in vital cellular mechanisms, including DNA repair and maintenance of genomic integrity. By removing the expression of this gene, researchers can gain insights into its contributions to cellular stress responses, apoptosis, and other critical physiological functions.
The key mechanism governing the functionality of EXD2 knockout cell lines is the targeted genomic editing employed during their creation, which typically involves techniques such as CRISPR-Cas9 or homologous recombination. This precise gene-editing technology ensures complete deletion of the EXD2 gene, allowing for a thorough investigation of phenotypic changes and functional consequences in various cellular contexts.
Scientifically, these cell lines hold immense importance for both fundamental and applied research, especially in studies related to cancer biology, neurodegenerative disorders, and drug development. By utilizing EXD2 knockout cell lines, researchers can explore the gene’s implications in disease mechanisms, assess the efficacy of novel therapeutics, and delineate signaling pathways impacted by EXD2.
Compared to alternatives, such as overexpression systems or wild-type controls, EXD2 knockout cell lines provide a more relevant and authentic model to study loss-of-function effects in relationship to disease. The precision of genetic ablation coupled with the ability to introduce specific mutations strategically equips investigators to generate reproducible and reliable data.
For researchers and clinicians alike, the value of EXD2 Gene Knockout Cell Lines is profound. They not only expedite the discovery and validation of critical biomolecular interactions but also foster advancements in targeted therapeutic strategies. Utilizing these specialized cell lines can significantly enhance research productivity and outcomes.
Our company takes pride in its reputation for delivering high-quality biological products backed by extensive expertise in genetic engineering and cellular models. With a commitment to advancing research methodologies, we provide reliable tools that empower the scientific community to push boundaries and achieve groundbreaking discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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