Gene: ETV1
Official Full Name: ETS variant transcription factor 1provided by HGNC
Gene Summary: This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Ewing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO05174 | ETV1 Knockout cell line (HeLa) | Human | ETV1 | 1:3~1:6 | Negative | Online Inquiry |
KO05175 | ETV1 Knockout cell line (HCT 116) | Human | ETV1 | 1:2~1:4 | Negative | Online Inquiry |
KO05176 | ETV1 Knockout cell line (HEK293) | Human | ETV1 | 1:3~1:6 | Negative | Online Inquiry |
KO05177 | ETV1 Knockout cell line (A549) | Human | ETV1 | 1:3~1:4 | Negative | Online Inquiry |
ETV1 Gene Knockout Cell Lines are an advanced genomic tool designed to facilitate the study of ETV1, a member of the E26 transformation-specific (ETS) family of transcription factors. These cell lines have been engineered to provide a definitive in vitro model for exploring the biological functions of ETV1, specifically its role in oncogenesis and regulation of gene expression. Utilizing CRISPR-Cas9 technology, the ETV1 gene has been effectively disrupted in these cell lines, allowing researchers to observe the resultant phenotypic changes and molecular pathways that are influenced by the absence of ETV1.
The primary function of these knockout cell lines lies in their ability to elucidate the specific contributions of ETV1 to cellular processes such as proliferation, differentiation, and apoptosis. By employing these models, scientists can investigate how ETV1 dysregulation may lead to various malignancies and other diseases, thereby providing critical insights into therapeutic targets for intervention. The relevance of ETV1 in cancer pathology and its potential as a biomarker for treatment responses make these cell lines invaluable for both basic research and translational applications.
One of the significant advantages of the ETV1 Gene Knockout Cell Lines is the precision afforded by the CRISPR-Cas9 editing technique. Unlike traditional knockout methods, this approach provides a higher specificity and efficiency, resulting in cleaner genetic backgrounds that minimize off-target effects. Additionally, these cell lines are carefully validated for robust performance in standard laboratory assays, making them reliable tools for researchers.
By employing ETV1 Gene Knockout Cell Lines, researchers gain access to a powerful platform that accelerates the discovery of novel therapeutic strategies against ETV1-linked conditions. The unique selling points lie not only in their state-of-the-art design but also in their ease-of-use and adaptability across various experimental setups, providing a seamless integration into ongoing research projects.
Our company specializes in delivering high-quality genetic models that empower scientific investigation and innovation. We are committed to supporting the research community with scientifically robust products like ETV1 Gene Knockout Cell Lines, which are tailored to meet the evolving needs of researchers and clinicians.
Please note that all services are for research use only. Not intended for any clinical use.
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