Gene: ETFA
Official Full Name: electron transfer flavoprotein subunit alphaprovided by HGNC
Gene Summary: ETFA participates in catalyzing the initial step of the mitochondrial fatty acid beta-oxidation. It shuttles electrons between primary flavoprotein dehydrogenases and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. Defects in electron-transfer-flavoprotein have been implicated in type II glutaricaciduria in which multiple acyl-CoA dehydrogenase deficiencies result in large excretion of glutaric, lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO37959 | ETFA Knockout cell line (HeLa) | Human | ETFA | 1:3~1:6 | Negative | Online Inquiry |
KO37960 | ETFA Knockout cell line (HCT 116) | Human | ETFA | 1:2~1:4 | Negative | Online Inquiry |
KO37961 | ETFA Knockout cell line (HEK293) | Human | ETFA | 1:3~1:6 | Negative | Online Inquiry |
KO37962 | ETFA Knockout cell line (A549) | Human | ETFA | 1:3~1:4 | Negative | Online Inquiry |
ETFA Gene Knockout Cell Lines are precision-model systems engineered to facilitate the study of gene function and regulation by specifically targeting and disabling the ETFA gene, which encodes the Electron Transport Flavoprotein Alpha subunit. These cell lines are developed using advanced genome-editing techniques, such as CRISPR/Cas9 technology, ensuring a reliable knockout at the genomic level. This enables researchers to investigate the cellular and molecular consequences of ETFA loss, including impacts on mitochondrial function, energy metabolism, and oxidative stress response pathways.
One key function of ETFA Gene Knockout Cell Lines is their ability to provide insights into metabolic disorders and their relevance to various disease states, including neurodegenerative diseases and cancers. By observing the behavioral changes of cellular processes in these knockout models, researchers can delineate the role of ETFA in cellular metabolism, aiding in the identification of potential therapeutic targets. The ability to create various backgrounds, including specific tissue types, further enhances their application across different lines of inquiry within biomedical research.
The scientific importance of these cell lines extends into both fundamental research and translational medicine. Understanding the mechanisms through which the ETFA gene contributes to metabolic regulation can lead to breakthroughs in personalized medicine strategies, aimed at modulating metabolic pathways responsible for disease progression. Compared to traditional methods of gene silencing, such as siRNA, these knockout cell lines provide a more permanent and stable genetic alteration, ensuring lasting insights into gene function.
Researchers and clinicians will find exceptional value in using ETFA Gene Knockout Cell Lines due to their specific design, which minimizes off-target effects and enhances experimental reproducibility. Furthermore, the simplicity of utilization in various in vitro assays offers researchers the versatility needed to conduct a wide range of studies efficiently.
At [Company Name], we leverage cutting-edge genetic engineering techniques to produce high-quality biological models that empower scientists to push the boundaries of discovery. Our expertise in developing precise cellular tools, like the ETFA Gene Knockout Cell Lines, ensures that you are equipped with the best resources to make substantive advancements in your research endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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