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EP300 Knockout Cell Lines

Gene: EP300

Official Full Name: E1A binding protein p300provided by HGNC

Gene Summary: This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01356 EP300 Knockout cell line (HeLa) Human EP300 1:3~1:6 Negative Online Inquiry
KO11311 EP300 Knockout cell line (HCT 116) Human EP300 1:2~1:4 Negative Online Inquiry
KO11312 EP300 Knockout cell line (HEK293) Human EP300 1:3~1:6 Negative Online Inquiry
KO11313 EP300 Knockout cell line (A549) Human EP300 1:3~1:4 Negative Online Inquiry

Background

EP300 Gene Knockout Cell Lines are sophisticated biological tools specifically engineered to study the functional role of the EP300 gene in various cellular processes. This gene encodes for a histone acetyltransferase, a critical enzyme involved in the regulation of gene expression through chromatin remodeling. By creating knockout models, researchers can examine the downstream effects of EP300 loss, providing insights into its involvement in cellular growth, differentiation, and oncogenesis. Each cell line is precision-targeted to ensure complete ablation of EP300, enabling an in-depth analysis of both its physiological and pathological roles.

The key function of these cell lines is to facilitate the dissection of cellular pathways modulated by the EP300 gene. By analyzing these knockout cell lines, researchers can employ a variety of techniques, including RNA sequencing, protein assays, and metabolic profiling, allowing them to elucidate the molecular mechanisms underpinning EP300’s regulatory functions. This targeted approach yields invaluable data that can inform therapeutic strategies, particularly in cancer research, where EP300 often plays a pivotal role.

In scientific and clinical communities, the significance of EP300 Gene Knockout Cell Lines cannot be overstated. They serve as a foundation for drug discovery, biomarker identification, and therapeutic interventions geared towards malignancies driven by aberrant gene expression. Compared to traditional approaches that may utilize overexpression or pharmacological inhibition, these knockout cell lines provide a more precise and accurate model of gene functionality, allowing for clearer interpretations of experimental results.

Furthermore, the unique value proposition of EP300 Gene Knockout Cell Lines lies in their ability to enhance experimental reproducibility and reliability, crucial for both academic research and clinical applications. Researchers and clinicians are increasingly reliant on high-fidelity models to push the boundaries of current biomedical knowledge, and our cell lines are designed to meet these demands with rigor and precision.

At our company, we are committed to advancing biological research through innovative products like the EP300 Gene Knockout Cell Lines. With a robust focus on quality and user support, we empower scientists to deepen their understanding of molecular biology and foster breakthroughs in medical research.

Please note that all services are for research use only. Not intended for any clinical use.

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