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ENTPD5 Knockout Cell Lines

Gene: ENTPD5

Official Full Name: ectonucleoside triphosphate diphosphohydrolase 5 (inactive)provided by HGNC

Gene Summary: The protein encoded by this gene is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases. [provided by RefSeq, Jan 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38647 ENTPD5 Knockout cell line (HeLa) Human ENTPD5 1:3~1:6 Negative Online Inquiry
KO38648 ENTPD5 Knockout cell line (HCT 116) Human ENTPD5 1:2~1:4 Negative Online Inquiry
KO38649 ENTPD5 Knockout cell line (HEK293) Human ENTPD5 1:3~1:6 Negative Online Inquiry
KO38650 ENTPD5 Knockout cell line (A549) Human ENTPD5 1:3~1:4 Negative Online Inquiry

Background

ENTPD5 Gene Knockout Cell Lines are genetically engineered models that facilitate comprehensive studies of the ENTPD5 gene’s function and its role in various biological processes. ENTPD5 encodes a nucleotide triphosphate diphosphohydrolase enzyme, pivotal in modulating extracellular nucleotides and influencing purinergic signaling pathways. The knockout of this gene provides researchers with a unique platform to investigate its implications in cellular metabolism, signal transduction, and potentially in pathological conditions such as cancer and neurodegenerative diseases.

These cell lines operate through the disruption of the ENTPD5 gene, leading to alterations in nucleotide hydrolysis, which may affect cell proliferation, differentiation, and apoptosis. This mechanism allows for the elucidation of ENTPD5's contribution to purine metabolism and its broader implications in the cellular microenvironment. Researchers can utilize these knockout models to explore therapeutic targets, assess drug efficacy, or evaluate disease mechanisms.

The scientific significance of ENTPD5 Gene Knockout Cell Lines is immense, paving the way for innovative research approaches in both basic and translational studies. Their application extends to drug discovery, genetic therapy, and understanding cell behavior in response to sitmuli. Unlike conventional models, these knockout cell lines provide a direct method to study the loss-of-function effects of ENTPD5, enabling more accurate and relevant biological insights.

The advantages of using ENTPD5 Gene Knockout Cell Lines include enhanced specificity for studying gene function, reduced variability in experimental outcomes, and robust reproducibility, making them superior to other models that may not fully recapitulate the genetic changes. By employing these sophisticated cell lines, researchers and clinicians can ensure more dependable data, which can lead to more effective therapeutic strategies.

Our commitment to advancing scientific knowledge is reflected in our expertise in providing high-quality cell line models that support cutting-edge research. We specialize in facilitating breakthroughs across various fields of biology, ensuring that our offerings remain indispensable tools for scientists dedicated to understanding complex biological systems.

Please note that all services are for research use only. Not intended for any clinical use.

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