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ENPP4 Knockout Cell Lines

Gene: ENPP4

Official Full Name: ectonucleotide pyrophosphatase/phosphodiesterase 4provided by HGNC

Gene Summary: Enables bis(5'-adenosyl)-triphosphatase activity. Involved in positive regulation of blood coagulation and purine ribonucleoside catabolic process. Located in extracellular exosome and membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO30228 ENPP4 Knockout cell line (HCT 116) Human ENPP4 1:2~1:4 Negative Online Inquiry
KO30229 ENPP4 Knockout cell line (HEK293) Human ENPP4 1:3~1:6 Negative Online Inquiry
KO30230 ENPP4 Knockout cell line (A549) Human ENPP4 1:3~1:4 Negative Online Inquiry

Background

ENPP4 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to lack the expression of the ENPP4 gene, which encodes ecto-nucleotide triphosphate diphosphohydrolase-1, a key enzyme associated with extracellular nucleotide metabolism. By completely eliminating ENPP4 expression, these cell lines allow researchers to study the effects of impaired nucleotide regulation on cellular functions and signaling pathways with unparalleled precision.

The core functionality of these knockout cell lines lies in their unique ability to serve as controlled experimental models for research into the physiological roles of ENPP4 and its impact on various biological processes, including cell proliferation, apoptosis, and inflammation. Through the mechanisms of gene loss and altered metabolic pathways, scientists can evaluate the broader implications of ENPP4 absence in various contexts such as cancer research, immune response studies, and metabolic disorders.

Scientifically, ENPP4 Gene Knockout Cell Lines hold immense importance not only in basic research but also in potential clinical applications. They are vital for investigating therapeutic targets and drug screening, specifically where nucleotide signaling plays a critical role. Their use in laboratory studies facilitates discoveries that could lead to novel treatment strategies and an enhanced understanding of disease mechanisms.

One of the standout advantages of ENPP4 Gene Knockout Cell Lines is their specificity and reliability compared to traditional methods like transient knockdown techniques or pharmacological inhibitors. The stable genetic modification ensures consistency across experiments while eliminating off-target effects, a common limitation in RNA interference approaches. This makes our product especially appealing for researchers who prioritize replicability and accuracy in their experiments.

For researchers, clinicians, and pharmaceutical companies, the ENPP4 Gene Knockout Cell Lines represent an invaluable tool in unlocking the complexities of nucleotide metabolism and its implications in health and disease. By providing a robust platform for innovative research, these cell lines enable investigators to pioneer advancements in therapeutic interventions.

Our company possesses extensive expertise in genetic engineering and cell line development, ensuring that our ENPP4 Gene Knockout Cell Lines are manufactured to the highest standards of quality and reproducibility. We are committed to advancing scientific research and are proud to offer cutting-edge biological products that empower the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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