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EHHADH Knockout Cell Lines

Gene: EHHADH

Official Full Name: enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenaseprovided by HGNC

Gene Summary: The protein encoded by this gene is a bifunctional enzyme and is one of the four enzymes of the peroxisomal beta-oxidation pathway. The N-terminal region of the encoded protein contains enoyl-CoA hydratase activity while the C-terminal region contains 3-hydroxyacyl-CoA dehydrogenase activity. Defects in this gene are a cause of peroxisomal disorders such as Zellweger syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38083 EHHADH Knockout cell line (HeLa) Human EHHADH 1:3~1:6 Negative Online Inquiry
KO38084 EHHADH Knockout cell line (HCT 116) Human EHHADH 1:2~1:4 Negative Online Inquiry
KO38085 EHHADH Knockout cell line (HEK293) Human EHHADH 1:3~1:6 Negative Online Inquiry
KO38086 EHHADH Knockout cell line (A549) Human EHHADH 1:3~1:4 Negative Online Inquiry

Background

EHHADH Gene Knockout Cell Lines represent a powerful biotechnological tool designed for researchers focused on elucidating the role of the EHHADH (Enoyl-CoA Hydratase/3-Hydroxyacyl-CoA Dehydrogenase) gene in various biological processes. These custom-engineered cell lines are generated using advanced CRISPR-Cas9 gene-editing technology, effectively creating a model where the EHHADH gene is non-functional. The EHHADH enzyme plays a critical role in fatty acid metabolism, specifically in the β-oxidation pathway, which makes it essential for understanding metabolic disorders, organ function, and various diseases including obesity and diabetes.

The primary function of these knockout cell lines is to provide researchers with a tool to investigate the consequences of EHHADH loss on cellular metabolism and overall physiology. By studying these knockout models, scientists can gain insight into potential compensatory pathways activated by EHHADH depletion, offering new perspectives on targeted therapies for metabolic diseases. The ability of these cell lines to mimic disease states enhances their relevance in both basic and applied biomedical research.

In contrast to traditional methods for studying gene function, EHHADH Gene Knockout Cell Lines offer specific advantages such as lower variability and more controlled experimental conditions, which contribute to more reproducible results. Furthermore, they prevent the off-target effects commonly associated with other genetic manipulation techniques, allowing for a clearer interpretation of experimental outcomes.

These cell lines will appeal to researchers and clinicians looking to investigate the molecular underpinnings of metabolic diseases, particularly those interested in therapeutic targets for interventions. Our commitment to delivering high-quality, precision tools is underscored by our team's extensive expertise in genetic engineering and cellular biology, ensuring reliability and innovative solutions in biological research. By incorporating EHHADH Gene Knockout Cell Lines into your studies, you equip yourself with a vital resource for breakthrough discoveries in metabolic research and therapy development.

Please note that all services are for research use only. Not intended for any clinical use.

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