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EFNB3 Knockout Cell Lines

Gene: EFNB3

Official Full Name: ephrin B3provided by HGNC

Gene Summary: EFNB3, a member of the ephrin gene family, is important in brain development as well as in its maintenance. Moreover, since levels of EFNB3 expression were particularly high in several forebrain subregions compared to other brain subregions, it may play a pivotal role in forebrain function. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH Receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38098 EFNB3 Knockout cell line (HEK293) Human EFNB3 1:3~1:6 Negative Online Inquiry

Background

EFNB3 Gene Knockout Cell Lines are precision-engineered cellular models specifically designed to investigate the functional roles of the Ephrin-B3 gene. These cell lines are created through advanced genetic engineering techniques, such as CRISPR/Cas9, resulting in the complete ablation of EFNB3 expression. The primary function of these cell lines is to serve as an invaluable tool for researchers studying the biological pathways associated with cell communication, migration, and axon guidance, which are critical processes in neurodevelopment and various pathological conditions.

The significance of the EFNB3 Gene Knockout Cell Lines lies in their ability to elucidate the implications of EFNB3 in diseases, including cancer and neurological disorders. By providing a controlled environment devoid of EFNB3 signaling, these cell lines enable researchers to better understand the downstream effects of its absence, thereby identifying potential therapeutic targets for intervention. In clinical applications, insights gained from studying these knockout models can translate into the development of targeted therapies that modulate ephrin signaling pathways.

One of the key advantages of EFNB3 Gene Knockout Cell Lines compared to traditional models is the specificity and precision of gene knockout achieved, which minimizes off-target effects common in other gene editing approaches. Additionally, these cell lines come with thorough validation and characterization, ensuring reliable experimental results. With their ease of use in various assays, including migration, proliferation, and signaling pathway analysis, these models are essential tools for both basic and translational research.

For researchers and clinicians seeking to advance their understanding of EFNB3’s role in cellular dynamics, these knockout cell lines offer an unparalleled opportunity to generate insights that can propel innovative treatments. Our company specializes in the development and provision of high-quality biological products, leveraging cutting-edge techniques and years of expertise in genetic engineering to support the scientific community in its quest for discovery and healing.

Please note that all services are for research use only. Not intended for any clinical use.

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