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EFNB1 Knockout Cell Lines

Gene: EFNB1

Official Full Name: ephrin B1provided by HGNC

Gene Summary: The protein encoded by this gene is a type I membrane protein and a ligand of Eph-related receptor tyrosine kinases. It may play a role in cell adhesion and function in the development or maintenance of the nervous system. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38103 EFNB1 Knockout cell line (HeLa) Human EFNB1 1:3~1:6 Negative Online Inquiry
KO38104 EFNB1 Knockout cell line (HCT 116) Human EFNB1 1:2~1:4 Negative Online Inquiry
KO38105 EFNB1 Knockout cell line (HEK293) Human EFNB1 1:3~1:6 Negative Online Inquiry
KO38106 EFNB1 Knockout cell line (A549) Human EFNB1 1:3~1:4 Negative Online Inquiry

Background

EFNB1 Gene Knockout Cell Lines are genetically modified cell lines specifically engineered to disable the EFNB1 gene, which encodes the Ephrin-B1 protein, a crucial component in cellular signaling and growth regulation. These knockout cell lines facilitate the study of the biological roles of Ephrin-B1 in various physiological processes, including cell adhesion, migration, and apoptosis, which are fundamental in cancer biology, neurobiology, and developmental biology.

The mechanism of action behind the EFNB1 Gene Knockout Cell Lines involves CRISPR-Cas9 gene editing technology, allowing for precise deletion of the EFNB1 gene. This targeted approach not only enables researchers to observe the resultant phenotypic changes but also permits in-depth exploration of the molecular pathways influenced by Ephrin-B1 activity. By using these knockout cell lines, scientists can ascertain the gene's contribution to oncogenic processes, neuromuscular disorders, and other pathophysiological conditions.

The scientific significance of these cell lines is profound, as they serve as robust models for understanding the implications of EFNB1 in various biological contexts. They are invaluable tools for drug discovery, target validation, and biomarker identification due to their ability to mimic the loss of function scenarios found in vivo. Additionally, they provide insights into therapeutic strategies that could potentially modulate Ephrin-B1 activity for disease treatment.

What sets EFNB1 Gene Knockout Cell Lines apart from alternatives is their specificity and reliability. Unlike non-specific gene inhibitors that can yield off-target effects, these knockout lines offer a clean, unequivocal way to study gene function without confounding variables. This specificity translates into higher reproducibility and more credible results, facilitating more robust scientific conclusions.

In summary, EFNB1 Gene Knockout Cell Lines represent an essential resource for researchers and clinicians aiming to investigate the multifaceted roles of Ephrin-B1 in health and disease. Leveraging decades of expertise in gene editing technology, our company is committed to providing high-quality biological products that empower researchers in their pursuit of discovery and innovation.

Please note that all services are for research use only. Not intended for any clinical use.

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