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EFEMP1 Knockout Cell Lines

Gene: EFEMP1

Official Full Name: EGF containing fibulin extracellular matrix protein 1provided by HGNC

Gene Summary: This gene encodes a member of the fibulin family of extracellular matrix glycoproteins. Like all members of this family, the encoded protein contains tandemly repeated epidermal growth factor-like repeats followed by a C-terminus fibulin-type domain. This gene is upregulated in malignant gliomas and may play a role in the aggressive nature of these tumors. Mutations in this gene are associated with Doyne honeycomb retinal dystrophy. Alternatively spliced transcript variants that encode the same protein have been described.[provided by RefSeq, Nov 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO03346 EFEMP1 Knockout cell line (HeLa) Human EFEMP1 1:3~1:6 Negative Online Inquiry
KO03347 EFEMP1 Knockout cell line (HEK293) Human EFEMP1 1:3~1:6 Negative Online Inquiry
KO03348 EFEMP1 Knockout cell line (A549) Human EFEMP1 1:3~1:4 Negative Online Inquiry

Background

EFEMP1 Gene Knockout Cell Lines are a cutting-edge biological tool designed to facilitate the study of the EFEMP1 gene, which encodes an extracellular matrix protein implicated in the modulation of cellular processes such as proliferation, migration, and adhesion. These cell lines are engineered through precise CRISPR/Cas9 technology to create complete gene knockouts, enabling researchers to investigate the specific roles of EFEMP1 in various biological contexts, including cancer progression, developmental biology, and tissue regeneration.

The primary function of EFEMP1 gene knockout cell lines is to serve as a model for understanding the physiological and pathological implications of EFEMP1 absence. By utilizing these cell lines, researchers can delve into the downstream effects on cellular signaling pathways, gene expression profiles, and the overall impact on cell behavior, thereby elucidating the functional dynamics of the EFEMP1 protein in health and disease.

In the scientific landscape, these knockout models carry significant relevance, particularly in translational research and drug discovery. As EFEMP1 has been linked to various disorders, including age-related macular degeneration and certain cancers, the ability to study its loss-of-function effects provides crucial insights that pave the way for targeted therapeutic strategies.

Compared to conventional cell lines, the EFEMP1 gene knockout cell lines offer unparalleled specificity and robustness in gene editing. The precision of CRISPR technology ensures high knockout efficiency and minimal off-target effects, thus bolstering experimental reliability. This specificity also allows for the study of precise mechanisms of action unlike broad-spectrum approaches that may yield confounding results.

By choosing EFEMP1 Gene Knockout Cell Lines, researchers and clinicians gain access to a powerful experimental system that enhances the understanding of EFEMP1's role in disease mechanisms. These models provide innovative platforms for drug testing, biomarker discovery, and the exploration of potential therapeutic interventions.

Our company is dedicated to providing high-quality biological products tailored to meet the evolving needs of the scientific community. With extensive expertise in gene editing technologies and cellular model development, we ensure that our products support the advancement of research and its translation into clinical applications.

Please note that all services are for research use only. Not intended for any clinical use.

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