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EEF1E1 Knockout Cell Lines

Gene: EEF1E1

Official Full Name: eukaryotic translation elongation factor 1 epsilon 1provided by HGNC

Gene Summary: This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO05538 EEF1E1 Knockout cell line (HeLa) Human EEF1E1 1:3~1:6 Negative Online Inquiry
KO05539 EEF1E1 Knockout cell line (HCT 116) Human EEF1E1 1:2~1:4 Negative Online Inquiry
KO05540 EEF1E1 Knockout cell line (HEK293) Human EEF1E1 1:3~1:6 Negative Online Inquiry
KO05541 EEF1E1 Knockout cell line (A549) Human EEF1E1 1:3~1:4 Negative Online Inquiry

Background

EEF1E1 Gene Knockout Cell Lines are genetically modified cellular models designed to provide researchers with the ability to investigate the biological roles of the EEF1E1 gene. This gene encodes a critical component of the elongation factor complex involved in mRNA translation, playing a vital role in protein synthesis within eukaryotic cells. By utilizing CRISPR/Cas9 technology, these cell lines have been engineered to possess a complete knockout of the EEF1E1 gene, allowing for clarity of EEF1E1’s function and its implication in cellular processes such as growth, differentiation, and stress responses.

The primary function of EEF1E1 is to facilitate the delivery of aminoacyl-tRNA to the ribosome, influencing the efficiency of protein synthesis. Through the knockout of this gene, researchers can elucidate downstream effects on translation fidelity and overall cellular metabolism, thereby providing crucial insights into potential dysregulation observed in various diseases, including certain cancers and neurodegenerative disorders. This makes the EEF1E1 knockout cell lines a valuable tool in both fundamental research and therapeutic development.

Compared to other genetic manipulation techniques, our knockout cell lines offer several advantages, including a higher degree of specificity in targeting the EEF1E1 gene and the elimination of off-target effects commonly associated with traditional RNA interference methods. This specificity ensures more reliable experimental outcomes and reproducibility, allowing researchers to focus on dissecting the molecular pathways influenced by EEF1E1 with reduced interference from unintended genetic variations.

For researchers and clinicians, these cell lines represent a significant asset, enabling advanced exploration into the role of EEF1E1 in protein synthesis and its broader implications in human health and disease. By understanding these mechanisms, scientists can identify new therapeutic avenues and stratify patient responses in drug trials.

With a commitment to quality and innovation, our company has established itself as a leader in providing cutting-edge biological products tailored to meet the needs of the research community. Our expertise in molecular biology and genetic engineering ensures that our EEF1E1 Gene Knockout Cell Lines are of the highest standards, empowering scientists to make impactful discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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