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EEF1A2 Knockout Cell Lines

Gene: EEF1A2

Official Full Name: eukaryotic translation elongation factor 1 alpha 2provided by HGNC

Gene Summary: This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 2) is expressed in brain, heart and skeletal muscle, and the other isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas. This gene may be critical in the development of ovarian cancer. [provided by RefSeq, Mar 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38111 EEF1A2 Knockout cell line (HeLa) Human EEF1A2 1:3~1:6 Negative Online Inquiry
KO38112 EEF1A2 Knockout cell line (HCT 116) Human EEF1A2 1:2~1:4 Negative Online Inquiry
KO38113 EEF1A2 Knockout cell line (HEK293) Human EEF1A2 1:3~1:6 Negative Online Inquiry
KO38114 EEF1A2 Knockout cell line (A549) Human EEF1A2 1:3~1:4 Negative Online Inquiry

Background

EEF1A2 Gene Knockout Cell Lines are specialized cellular models engineered to lack the expression of the EEF1A2 gene, which encodes the eukaryotic elongation factor 1 alpha 2. This gene plays a crucial role in the translation process by facilitating the delivery of aminoacyl-tRNA to the ribosome, thus influencing protein synthesis. By utilizing genetic engineering techniques such as CRISPR-Cas9, these knockout cell lines allow researchers to investigate the functional implications of EEF1A2 depletion on cellular metabolism, proliferation, and disease states.

The primary mechanism of action of EEF1A2 Gene Knockout Cell Lines involves the elimination of EEF1A2 protein production, which can lead to alterations in protein synthesis dynamics, cellular stress responses, and potentially aberrant cellular behaviors associated with various pathologies, including cancer. Such models provide indispensable insights into the biological role of EEF1A2 in cell signaling and growth, paving the way for novel therapeutic strategies targeting translation-related pathways.

In a scientific context, these knockout cell lines are invaluable for researchers seeking to elucidate the molecular underpinnings of diseases, develop targeted therapies, or explore the consequences of altered protein synthesis in cellular contexts. Their applications span diverse fields, including oncology, neurobiology, and immunology, making them a versatile addition to the research toolkit.

What sets EEF1A2 Gene Knockout Cell Lines apart is their specificity and reliability; unlike traditional models, these lines offer a controlled environment that precisely replicates the absence of EEF1A2, minimizing off-target effects and enhancing reproducibility in experimental outcomes. Moreover, these cell lines can be adapted for high-throughput screening, increasing their utility for both academic and pharmaceutical research.

Researchers and clinicians will find significant value in incorporating EEF1A2 Gene Knockout Cell Lines into their studies, as they provide crucial insights into gene function, disease mechanisms, and therapeutic avenues. This innovative product taps into your research inquiries and assists in the pursuit of scientific knowledge that can lead to the next breakthroughs in healthcare.

Our company boasts extensive expertise in cellular model development, combining cutting-edge technology with a commitment to providing high-quality biological products tailored to meet the specific needs of the research community.

Please note that all services are for research use only. Not intended for any clinical use.

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