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ECM1 Knockout Cell Lines

Gene: ECM1

Official Full Name: extracellular matrix protein 1provided by HGNC

Gene Summary: This gene encodes a soluble protein that is involved in endochondral bone formation, angiogenesis, and tumor biology. It also interacts with a variety of extracellular and structural proteins, contributing to the maintenance of skin integrity and homeostasis. Mutations in this gene are associated with lipoid proteinosis disorder (also known as hyalinosis cutis et mucosae or Urbach-Wiethe disease) that is characterized by generalized thickening of skin, mucosae and certain viscera. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00297 ECM1 Knockout cell line (HCT 116) Human ECM1 1:2~1:4 Negative Online Inquiry
KO38127 ECM1 Knockout cell line (HeLa) Human ECM1 1:3~1:6 Negative Online Inquiry
KO38128 ECM1 Knockout cell line (HEK293) Human ECM1 1:3~1:6 Negative Online Inquiry
KO38129 ECM1 Knockout cell line (A549) Human ECM1 1:3~1:4 Negative Online Inquiry

Background

ECM1 Gene Knockout Cell Lines represent a significant advancement in molecular biology, providing researchers with tailored model systems to investigate the role of the ECM1 gene in various biological processes. These genetically modified cell lines have been engineered to lack functional ECM1 expression, allowing for the dissection of its contribution to cellular mechanisms, such as cell adhesion, proliferation, and signaling pathways.

The key function of ECM1, an extracellular matrix protein, is its involvement in extracellular matrix composition and regulation, which directly influences tissue homeostasis and cell-matrix interactions. By utilizing ECM1 Gene Knockout Cell Lines, researchers can elucidate the downstream effects of ECM1 deficiency on cellular behaviors and investigate its implication in diseases, including cancer metastasis and fibrosis. The mechanism of action is rooted in the gene-editing technology employed, typically CRISPR/Cas9 or RNA interference, which ensures precise and effective knockout of ECM1, resulting in a stable cell line ready for in-depth analysis.

These cell lines hold profound scientific importance, primarily in research contexts focused on developmental biology, cancer research, and regenerative medicine. The ability to study the direct impact of the absence of ECM1 makes these cell lines invaluable tools for investigating the complex interplay between cells and the extracellular matrix in both normal physiology and pathological conditions.

Compared to traditional wild-type cell lines, ECM1 Gene Knockout Cell Lines offer several advantages: they provide a controlled environment to study gene function without the confounding effects of ECM1 expression, enabling clearer interpretation of experimental results. This specificity enhances experimental reproducibility and can lead to novel therapeutic insights that might be missed when analyzing mixed cell populations.

For researchers and clinicians, utilizing ECM1 Gene Knockout Cell Lines means accessing a powerful platform that can drive innovation in understanding ECM1-associated pathologies and therapies. Moreover, leveraging these cell lines can significantly streamline experimental workflows, ultimately leading to quicker, more robust findings.

At [Your Company Name], we pride ourselves on expertise in gene editing technologies and the development of high-quality biological products, such as ECM1 Gene Knockout Cell Lines. Our commitment to precision and reliability ensures that you receive the best resources to advance your research and clinical applications.

Please note that all services are for research use only. Not intended for any clinical use.

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