Gene: ECI2
Official Full Name: enoyl-CoA delta isomerase 2provided by HGNC
Gene Summary: This gene encodes a member of the hydratase/isomerase superfamily. The protein encoded is a key mitochondrial enzyme involved in beta-oxidation of unsaturated fatty acids. It catalyzes the transformation of 3-cis and 3-trans-enoyl-CoA esters arising during the stepwise degradation of cis-, mono-, and polyunsaturated fatty acids to the 2-trans-enoyl-CoA intermediates. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01927 | ECI2 Knockout cell line (HeLa) | Human | ECI2 | 1:3~1:6 | Negative | Online Inquiry |
KO01928 | ECI2 Knockout cell line (HCT 116) | Human | ECI2 | 1:2~1:4 | Negative | Online Inquiry |
KO01929 | ECI2 Knockout cell line (HEK293) | Human | ECI2 | 1:3~1:6 | Negative | Online Inquiry |
KO01930 | ECI2 Knockout cell line (A549) | Human | ECI2 | 1:3~1:4 | Negative | Online Inquiry |
ECI2 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to silence the expression of the ECI2 gene, a critical player in lipid metabolism and involved in various cellular processes such as energy homeostasis and fatty acid oxidation. These cell lines utilize CRISPR-Cas9 technology, a precise and widely accepted gene-editing tool that employs guide RNA sequences to direct the Cas9 nuclease to produce double-strand breaks in target DNA, subsequently leading to the disruption of the ECI2 gene. This mechanism allows researchers to study the effects of the absence of ECI2 on cellular function and metabolism, providing insights into its role in diseases associated with lipid disorders.
The scientific importance of ECI2 Gene Knockout Cell Lines extends to their applications in both research and clinical settings. They serve as vital models for investigating the physiological consequences of ECI2 deficiency, including potential links to metabolic syndromes, obesity, and cardiovascular diseases. Moreover, these cell lines are invaluable for drug development, enabling researchers to screen for compounds that can modulate ECI2 activity or assess therapeutic strategies for related disorders.
What sets ECI2 Gene Knockout Cell Lines apart from other genetic models is their high specificity and reliability in gene editing, minimizing off-target effects that are often associated with alternative methods. These cell lines come with robust validation protocols, ensuring that the knockout is functionally and phenotypically confirmed, thus providing confidence in experimental outcomes.
For researchers and clinicians, the value of ECI2 Gene Knockout Cell Lines lies in their ability to facilitate groundbreaking discoveries in the field of metabolic research swiftly and accurately. By offering a targeted approach to gene functionality studies, these cell lines empower users to unravel complex biological pathways and develop innovative therapeutic strategies.
At [Your Company Name], we pride ourselves on our cutting-edge genetic engineering expertise and commitment to supporting the scientific community with high-quality biological products. With our ECI2 Gene Knockout Cell Lines, researchers can access advanced tools that propel their investigations and accelerate the path towards impactful discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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