Gene: E2F8
Official Full Name: E2F transcription factor 8provided by HGNC
Gene Summary: This gene encodes a member of a family of transcription factors which regulate the expression of genes required for progression through the cell cycle. The encoded protein regulates progression from G1 to S phase by ensuring the nucleus divides at the proper time. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO18097 | E2F8 Knockout cell line (HeLa) | Human | E2F8 | 1:3~1:6 | Negative | Online Inquiry |
KO18098 | E2F8 Knockout cell line (HCT 116) | Human | E2F8 | 1:2~1:4 | Negative | Online Inquiry |
KO18099 | E2F8 Knockout cell line (HEK293) | Human | E2F8 | 1:3~1:6 | Negative | Online Inquiry |
KO18100 | E2F8 Knockout cell line (A549) | Human | E2F8 | 1:3~1:4 | Negative | Online Inquiry |
E2F8 Gene Knockout Cell Lines are specialized cellular models that have been genetically engineered to lack the expression of the E2F8 gene, a key regulator involved in cell cycle control and transcriptional regulation. These cell lines serve as vital tools for researchers investigating the role of E2F8 in various biological processes, particularly in cancer biology where E2F family members are often implicated in tumor proliferation and progression.
The primary mechanism by which E2F8 influences cellular function revolves around its ability to regulate the genes involved in the cell cycle and DNA synthesis. By knocking out E2F8, researchers can effectively elucidate the downstream effects on cell cycle dynamics, apoptosis, and differentiation, providing insights into the molecular pathways that are critical for understanding oncogenesis and potential therapeutic targets.
These cell lines hold significant scientific importance as they allow for the detailed study of E2F8's contributions in both mechanistic and applied research settings. Their utility extends to pharmacological studies where drugs targeting the E2F pathway can be evaluated for their efficacy and safety in preclinical models. Furthermore, E2F8 Gene Knockout Cell Lines are valuable in gene therapy research, allowing for the examination of compensatory mechanisms activated by the absence of E2F8.
Compared to alternative cell models, these knockout lines offer several advantages. They provide a distinct and controlled environment to study the specific effects of E2F8 absence without the confounding variables present in wild-type lines. Additionally, researchers can be assured of the reproducibility and reliability of the results, as these knockout lines are generated using cutting-edge CRISPR-Cas9 technology, ensuring precise gene editing and validation.
For researchers and clinicians alike, E2F8 Gene Knockout Cell Lines represent an indispensable resource that enhances the understanding of cell cycle regulation and its implications in disease. The potential for these models to uncover novel therapeutic strategies is substantial, making them a valuable addition to any research portfolio.
At our company, we pride ourselves on our commitment to advancing molecular biology and genetics research. With a dedicated team of experts and a focus on high-quality, reliable biological reagents, we ensure that our products, including E2F8 Gene Knockout Cell Lines, are designed to facilitate breakthroughs in science and medicine.
Please note that all services are for research use only. Not intended for any clinical use.
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