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DYNLT1 Knockout Cell Lines

Gene: DYNLT1

Official Full Name: dynein light chain Tctex-type 1provided by HGNC

Gene Summary: This gene encodes a component of the motor complex, cytoplasmic dynein, which transports cellular cargo along microtubules in the cell. The encoded protein regulates the length of primary cilia which are sensory organelles found on the surface of cells. The protein encoded by this gene interacts with viral proteins, like the minor capsid protein L2 of human papillomavirus, and is required for dynein-mediated delivery of the viral nucleic acid to the host nucleus. This protein interacts with oncogenic nucleoporins to disrupt gene regulation and cause leukemic transformation. Pseudogenes of this gene are present on chromosomes 4 and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35063 DYNLT1 Knockout cell line (HeLa) Human DYNLT1 1:3~1:6 Negative Online Inquiry
KO35064 DYNLT1 Knockout cell line (HCT 116) Human DYNLT1 1:2~1:4 Negative Online Inquiry
KO35065 DYNLT1 Knockout cell line (HEK293) Human DYNLT1 1:3~1:6 Negative Online Inquiry
KO35066 DYNLT1 Knockout cell line (A549) Human DYNLT1 1:3~1:4 Negative Online Inquiry

Background

DYNLT1 Gene Knockout Cell Lines represent a powerful tool in genetic research and functional genomics designed to facilitate the study of the DYNLT1 gene and its associated pathways. These cell lines are engineered to have a complete knockout of the DYNLT1 gene, which encodes for a dynein light chain involved in intracellular transport and signal transduction. By eliminating the expression of this gene, researchers can effectively investigate the downstream effects on various cellular processes, such as mitosis, apoptosis, and cellular motility.

The primary function of DYNLT1 Gene Knockout Cell Lines lies in their ability to provide insightful data on the role of DYNLT1 in cellular physiology and pathology. The knockout mechanism works through the use of CRISPR/Cas9 technology, which allows for precise deletions and alterations of the genomic region of interest, ensuring that the lack of DYNLT1 expression can be studied in a controlled environment.

In terms of scientific importance, these cell lines are invaluable for research into neurodegenerative diseases, cancer biology, and other conditions where dynein-related transport mechanisms may be disrupted. They serve as essential models for drug discovery and testing, enabling researchers to assess therapeutic targets related to dynein-related pathways and to explore novel intervention strategies.

Compared to alternative models, DYNLT1 Gene Knockout Cell Lines offer highly specific genetic modifications that conventional knockdown methods, such as RNA interference, may not achieve comprehensively. The robust nature of these knockout lines ensures their long-term stability, reproducibility, and ease of use across various applications, making them a preferred choice for meticulous research.

These cell lines empower researchers and clinicians alike by providing them with the ability to delve deeper into the functional roles of DYNLT1, allowing for breakthroughs in understanding complex genetic interactions and their implications in health and disease. Our company is committed to advancing biological research through high-quality products such as these, backed by extensive expertise in gene editing technologies and a dedication to supporting scientists in their quest for discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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