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DYNC2I1 Knockout Cell Lines

Gene: DYNC2I1

Official Full Name: dynein 2 intermediate chain 1provided by HGNC

Gene Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) and may facilitate the formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. The encoded protein contains four WD repeats and may play a role in the formation of cilia. Mutations in this gene have been associated with short-rib polydactyly and Jeune syndromes. [provided by RefSeq, Mar 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO18117 DYNC2I1 Knockout cell line (HeLa) Human DYNC2I1 1:3~1:6 Negative Online Inquiry
KO18118 DYNC2I1 Knockout cell line (HCT 116) Human DYNC2I1 1:2~1:4 Negative Online Inquiry
KO18119 DYNC2I1 Knockout cell line (HEK293) Human DYNC2I1 1:3~1:6 Negative Online Inquiry
KO18120 DYNC2I1 Knockout cell line (A549) Human DYNC2I1 1:3~1:4 Negative Online Inquiry

Background

DYNC2I1 Gene Knockout Cell Lines represent a powerful tool in the field of genetic and cellular research, specifically designed to facilitate the study of the DYNC2I1 gene's role in various biological processes. These cell lines have been engineered using CRISPR-Cas9 technology to create precise deletions within the DYNC2I1 gene, effectively rendering it non-functional. This knockout allows researchers to observe the resulting phenotypic changes and elucidate the gene's involvement in cellular mechanisms such as intracellular transport, cellular motility, and neural development.

The key function of the DYNC2I1 knockout is its ability to disrupt the dynein motor complex, which is crucial for retrograde axonal transport. By investigating these cell lines, scientists can explore the implications of DYNC2I1 dysfunction in diseases characterized by impaired neuronal transport and degeneration, such as neurodegenerative disorders and muscular dystrophies. This product is particularly valuable in preclinical research settings, enabling researchers to model and study the pathophysiology of various genetic diseases more effectively.

What sets our DYNC2I1 Gene Knockout Cell Lines apart from traditional models is our commitment to precision and reproducibility. These cell lines are validated with high specificity, ensuring reliable results that can be correlated across experiments. Additionally, they come with comprehensive support, including detailed protocols and optimization services tailored to enhance experimental outcomes.

For researchers and clinicians exploring the intricacies of genetic regulation and disease mechanisms, our DYNC2I1 Gene Knockout Cell Lines offer an unmatched combination of accuracy, reliability, and ease of use. They are an invaluable resource for advancing understanding in the field of molecular genetics and developing targeted therapeutic strategies.

Our company is dedicated to innovation in biological products, backed by a robust background in genetic research and biotechnological advancements. We strive to provide top-quality resources that empower scientists to make significant discoveries in their respective fields.

Please note that all services are for research use only. Not intended for any clinical use.

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