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DUSP2 Knockout Cell Lines

Gene: DUSP2

Official Full Name: dual specificity phosphatase 2provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO10864 DUSP2 Knockout cell line (HeLa) Human DUSP2 1:3~1:6 Negative Online Inquiry
KO10865 DUSP2 Knockout cell line (HCT 116) Human DUSP2 1:2~1:4 Negative Online Inquiry

Background

DUSP2 Gene Knockout Cell Lines are genetically engineered cell lines that have undergone targeted gene editing to disrupt the expression of the Dual Specificity Phosphatase 2 (DUSP2) gene. DUSP2 is known for its role in modulating MAPK pathways, impacting cellular responses to stress, inflammation, and other physiological stimuli. These knockout cell lines provide a platform for studying the functional implications of DUSP2 absence in various biological processes and disease models.

The key mechanism underlying DUSP2 knockout involves the use of CRISPR-Cas9 gene editing technology, which allows precise modifications of the genomic sequence. This leads to the loss of DUSP2 function, subsequently enabling researchers to investigate the resultant phenotypic changes in cellular behavior. DUSP2 is implicated in numerous signaling pathways; its knockout can thus elucidate its role in processes such as cell proliferation, apoptosis, and immune response modulation. This is particularly relevant in the context of cancer and autoimmune disorders, where DUSP2 may contribute to disease progression and therapeutic resistance.

In research and clinical settings, DUSP2 Gene Knockout Cell Lines are invaluable for elucidating the molecular underpinnings of diseases, testing therapeutic interventions, and screening drug candidates. They provide a robust platform for functional assays, biomarker discovery, and the development of personalized medicine approaches.

The advantages of DUSP2 knockout cell lines include their specificity and reproducibility, offering a reliable model for studying the gene's functional role compared to non-targeted experimental approaches. Furthermore, these cell lines are amenable to high-throughput screening, saving time and resources while yielding significant insights.

For researchers and clinicians seeking to deepen their understanding of MAPK signaling and its implications in health and disease, DUSP2 Gene Knockout Cell Lines represent a critical resource. By utilizing our advanced gene editing technologies and cell culture expertise, we provide products that empower scientific discovery and accelerate the development of innovative therapeutic strategies.

Please note that all services are for research use only. Not intended for any clinical use.

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