Gene: Dsp
Official Full Name: desmoplakinprovided by RGD
Gene Summary: Predicted to enable protein kinase C binding activity; scaffold protein binding activity; and structural molecule activity. Predicted to be involved in several processes, including intermediate filament organization; regulation of heart contraction; and ventricular compact myocardium morphogenesis. Predicted to act upstream of or within adherens junction organization; desmosome organization; and epithelial cell-cell adhesion. Located in desmosome and fascia adherens. Human ortholog(s) of this gene implicated in Carvajal syndrome; arrhythmogenic right ventricular cardiomyopathy; arrhythmogenic right ventricular dysplasia 8; dilated cardiomyopathy; and keratosis palmoplantaris striata 2. Orthologous to human DSP (desmoplakin). [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38158 | DSP Knockout cell line (HeLa) | Human | DSP | 1:3~1:6 | Negative | Online Inquiry |
KO38159 | DSP Knockout cell line (HCT 116) | Human | DSP | 1:2~1:4 | Negative | Online Inquiry |
KO38160 | DSP Knockout cell line (HEK293) | Human | DSP | 1:3~1:6 | Negative | Online Inquiry |
KO38161 | DSP Knockout cell line (A549) | Human | DSP | 1:3~1:4 | Negative | Online Inquiry |
Dsp Gene Knockout Cell Lines are precisely engineered cellular models that have been modified to disrupt the expression of the Dsp gene, important for various biological processes. These knockout cell lines serve as essential tools in understanding gene function, elucidating disease mechanisms, and validating potential therapeutic targets. By employing CRISPR-Cas9 technology or other gene-editing methods, the Dsp Gene Knockout Cell Lines effectively produce a complete loss of function for the targeted gene, allowing researchers to investigate the resultant phenotypic changes and their underlying molecular pathways.
The primary mechanism of action involves the targeted editing of the genome to induce frameshift mutations within the Dsp gene, leading to a nonfunctional protein. This alteration provides valuable insight into the role of Dsp in cellular differentiation, signaling pathways, and tissue homeostasis. In clinical and research settings, these cell lines have been imperative for gaining a deeper understanding of various pathological states, including cancer, cardiovascular diseases, and developmental disorders.
The Dsp Gene Knockout Cell Lines stand apart from conventional models due to their specificity and reproducibility, allowing for high-throughput screening and experimental consistency. Unlike transient knockdown approaches, which can yield variable results, the Dsp knockout models ensure stable gene loss, providing a reliable platform for drug discovery and functional genomics. Researchers benefit from the time-saving aspect of these pre-characterized cell lines, which provide enhanced biological relevance and confidence in experimental outcomes.
In summary, the Dsp Gene Knockout Cell Lines offer invaluable advantages for scientists and clinicians focused on genetic research and therapeutic innovation. Backed by our company's commitment to advancing biological research, these cell lines represent a critical asset for cutting-edge studies in gene function and disease modeling, enabling our partners to make significant strides in biomedical science.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.