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DPYSL5 Knockout Cell Lines

Gene: DPYSL5

Official Full Name: dihydropyrimidinase like 5provided by HGNC

Gene Summary: This gene encodes a member of the CRMP (collapsing response mediator protein) family thought to be involved in neural development. Antibodies to the encoded protein were found in some patients with neurologic symptoms who had paraneoplastic syndrome. A pseudogene of this gene is found on chromosome 11. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO05630 DPYSL5 Knockout cell line (HCT 116) Human DPYSL5 1:2~1:4 Negative Online Inquiry
KO05631 DPYSL5 Knockout cell line (HEK293) Human DPYSL5 1:3~1:6 Negative Online Inquiry
KO05632 DPYSL5 Knockout cell line (A549) Human DPYSL5 1:3~1:4 Negative Online Inquiry

Background

DPYSL5 Gene Knockout Cell Lines are genetically engineered cellular models that provide researchers with a powerful tool for investigating the role of the DPYSL5 gene in various biological processes and pathologies. These cell lines are created through the efficient application of CRISPR-Cas9 technology, leading to the targeted disruption of the DPYSL5 gene, which is known for its involvement in neuronal development, axon guidance, and synaptic plasticity.

The primary function of these cell lines is to facilitate the study of DPYSL5's contributions to cellular mechanisms such as cytoskeletal dynamics and signal transduction, essential for understanding neurodevelopmental disorders and neurodegenerative diseases. By observing the phenotypic changes in these knockout cell lines, researchers can unravel the gene's implications in cognitive functions, neurological disorders, and cancer biology.

From a scientific perspective, DPYSL5 Gene Knockout Cell Lines hold great importance in both academic and clinical settings, serving as robust models for drug development and therapeutic interventions. These cell lines can be utilized in high-throughput screening assays, allowing for the identification of novel compounds that modulate DPYSL5-related pathways. Additionally, they provide insight into gene-gene interactions and the biological effects of DPYSL5 loss, enhancing our understanding of its evolutionary conservation as a key regulator in the nervous system.

Compared to traditional cell models or less efficient knockout strategies, the DPYSL5 Gene Knockout Cell Lines stand out due to their precise gene targeting, consistent and reproducible results, and the ease of integration into existing research frameworks. The specificity afforded by CRISPR-Cas9 means researchers can elicit targeted cellular responses, minimizing off-target effects.

For researchers and clinicians aiming to elucidate the complexities of neurobiology or conduct targeted drug discovery, these cell lines represent an invaluable resource. They pave the way for advancements in genetics, molecular biology, and therapeutic development, making significant contributions to knowledge that can translate into clinical breakthroughs.

With our company's extensive expertise in genetic engineering and commitment to delivering high-quality biological products, we invite researchers to leverage the unique capabilities of the DPYSL5 Gene Knockout Cell Lines in their quest for scientific discovery and innovation.

Please note that all services are for research use only. Not intended for any clinical use.

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