Gene: DOCK7
Official Full Name: dedicator of cytokinesis 7provided by HGNC
Gene Summary: The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that plays a role in axon formation and neuronal polarization. The encoded protein displays GEF activity toward RAC1 and RAC3 Rho small GTPases but not toward CDC42. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO24219 | DOCK7 Knockout cell line (HeLa) | Human | DOCK7 | 1:3~1:6 | Negative | Online Inquiry |
KO24220 | DOCK7 Knockout cell line (HCT 116) | Human | DOCK7 | 1:2~1:4 | Negative | Online Inquiry |
KO24221 | DOCK7 Knockout cell line (HEK293) | Human | DOCK7 | 1:3~1:6 | Negative | Online Inquiry |
KO24222 | DOCK7 Knockout cell line (A549) | Human | DOCK7 | 1:3~1:4 | Negative | Online Inquiry |
DOCK7 Gene Knockout Cell Lines are specifically engineered cellular models that facilitate the study of the DOCK7 gene's function by enabling its complete genetic inactivation. The DOCK7 gene encodes for a member of the DOCK (Dedicator of Cytokinesis) family of proteins, which are pivotal in regulating various cellular processes including cytoskeletal dynamics, cell signaling, and neuronal development. Utilizing advanced CRISPR/Cas9 technology, these knockout cell lines provide a powerful tool for researchers to dissect the biological roles of DOCK7, thereby enhancing understanding of its implications in neurodevelopmental disorders and cancer pathways.
The key function of these knockout cell lines lies in their ability to selectively abrogate DOCK7 expression, allowing for the investigation of downstream effects on cellular pathways and phenotypes. By observing the resultant changes in cell morphology, migration, and differentiation, researchers can uncover critical insights into DOCK7-related mechanisms, providing a clearer understanding of its contributions to various pathophysiological conditions.
From a scientific standpoint, the DOCK7 Gene Knockout Cell Lines are invaluable for both basic and applied research. They serve as a foundational platform for drug discovery and the development of therapeutic strategies targeting DOCK7-related disorders. Furthermore, the ability to mimic specific genetic conditions in vitro facilitates the exploration of potential biomarkers and therapeutic interventions, thus bridging the gap between laboratory research and clinical applications.
One significant advantage of our DOCK7 Gene Knockout Cell Lines is the precision and reliability afforded by our optimized CRISPR-Cas9 design and validation process. Compared to conventional knockout models, these cell lines display consistent gene editing efficiency and reduced off-target effects. This specificity not only increases the reliability of experimental outcomes but also enhances reproducibility, a critical factor in scientific research.
Target users, including researchers and clinicians, will find tremendous value in utilizing DOCK7 Gene Knockout Cell Lines for generating robust experimental data that can lead to innovative breakthroughs in understanding DOCK7's role in health and disease. Our commitment to high-quality biological products, coupled with our expertise in genetic engineering, positions us as a leading provider of advanced tools for researchers aiming to propel their work forward with confidence.
Please note that all services are for research use only. Not intended for any clinical use.
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