Gene: DOCK5
Official Full Name: dedicator of cytokinesis 5provided by HGNC
Gene Summary: This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family act as guanine nucleotide exchange factors for small Rho family G proteins. The protein encoded by this gene is thought to associate with adaptors CRK and CRKL, and function in regulation of intestinal epithelial cell spreading and migration on collagen IV. Similar proteins in mouse and zebrafish also function in myoblast fusion. [provided by RefSeq, Oct 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO07059 | DOCK5 Knockout cell line (HeLa) | Human | DOCK5 | 1:3~1:6 | Negative | Online Inquiry |
KO07060 | DOCK5 Knockout cell line (HCT 116) | Human | DOCK5 | 1:2~1:4 | Negative | Online Inquiry |
KO07061 | DOCK5 Knockout cell line (HEK293) | Human | DOCK5 | 1:3~1:6 | Negative | Online Inquiry |
KO07062 | DOCK5 Knockout cell line (A549) | Human | DOCK5 | 1:3~1:4 | Negative | Online Inquiry |
DOCK5 Gene Knockout Cell Lines are specifically engineered cellular models designed to facilitate the investigation of the DOCK5 gene, which encodes a member of the DOCK (Dedicator of Cytokinesis) family of proteins. These knockout cell lines are generated through advanced gene-editing techniques, such as CRISPR/Cas9, resulting in the complete ablation of the DOCK5 gene expression. This precise genetic alteration allows researchers to delve deeper into the functional roles of DOCK5 within cellular processes, including cell differentiation, migration, and signaling pathways crucial for various physiological and pathological conditions.
The functionality of DOCK5 knockouts is primarily seen in their altered cellular behavior, which provide valuable insights into the gene's contribution to cellular dynamics and disease mechanisms. By eliminating DOCK5, scientists can observe changes in actin cytoskeletal organization and how these alterations impact processes such as immune response, cancer progression, and neural development. The ability to study these mechanisms in vitro is vital for advancing our understanding of complex biological systems and developing targeted therapeutic interventions.
The scientific importance of DOCK5 Gene Knockout Cell Lines extends into both research and clinical applications. In cancer research, for example, these cell lines can help unravel the role of DOCK5 in tumor metastasis and provide a platform for testing new anti-cancer strategies. Additionally, they serve as crucial tools in neurobiology, enabling investigations into neuronal signaling and synaptic plasticity.
Compared to traditional methods of gene silencing, such as RNA interference, our DOCK5 Gene Knockout Cell Lines offer superior specificity and permanence, ensuring consistent results across experiments. Furthermore, the ability to generate multiple independent knockouts enhances the robustness of experimental findings, allowing for comprehensive validation of results.
For researchers and clinicians aiming to produce reliable and reproducible data, these knockout cell lines stand out as invaluable resources. Their capacity to contribute to innovative discoveries underscores their significance in the ongoing efforts to decode complex biological phenomena.
Our commitment to excellence in cellular models is backed by years of expertise in the field, ensuring that our DOCK5 Gene Knockout Cell Lines are developed using state-of-the-art techniques and stringent quality controls. This dedication positions us as a leading provider of high-quality biological products that empower researchers and clinicians to achieve their scientific goals.
Please note that all services are for research use only. Not intended for any clinical use.
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