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DOCK10 Knockout Cell Lines

Gene: DOCK10

Official Full Name: dedicator of cytokinesis 10provided by HGNC

Gene Summary: This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family are guanosine nucleotide exchange factors for Rho GTPases and defined by the presence of conserved DOCK-homology regions. The encoded protein belongs to the D (or Zizimin) subfamily of DOCK proteins, which also contain an N-terminal pleckstrin homology domain. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Mar 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO18191 DOCK10 Knockout cell line (HeLa) Human DOCK10 1:3~1:6 Negative Online Inquiry
KO18192 DOCK10 Knockout cell line (A549) Human DOCK10 1:3~1:4 Negative Online Inquiry

Background

DOCK10 Gene Knockout Cell Lines are specialized cellular models that have been engineered to selectively disable the DOCK10 gene, a key regulator of various signaling pathways related to cell migration and development. By employing advanced CRISPR-Cas9 gene editing technology, our cell lines provide a precise means to investigate the role of DOCK10 in diverse biological processes, enabling researchers to gain insights into its function and contributions to disease mechanisms.

The primary function of DOCK10 is its role as a guanine nucleotide exchange factor (GEF), which activates Rho-family GTPases, thereby influencing cytoskeletal dynamics and cellular motility. By utilizing our DOCK10 knockout cell lines, researchers can observe the functional consequences of reduced DOCK10 activity, allowing for the elucidation of its involvement in immune responses, cancer metastasis, and developmental biology. This powerful tool is particularly useful in both basic and applied research settings, offering a robust platform for drug discovery and the development of novel therapeutic strategies.

The scientific importance of the DOCK10 Gene Knockout Cell Lines cannot be overstated. In clinical research, understanding the mechanisms underlying DOCK10's signaling pathways can lead to the identification of therapeutic targets for diseases such as cancer and immune disorders. Our product enables high-throughput screening of potential drugs by providing a reliable model to study the functional impacts of interventions on cellular behavior.

In comparison to traditional knockout methods or even other gene-editing technologies, our DOCK10 cell lines ensure high specificity and efficiency, minimizing off-target effects. Moreover, they can be adapted for use in various experimental conditions and assays, enhancing their versatility.

For researchers and clinicians aiming to drive innovation in their studies, the DOCK10 Gene Knockout Cell Lines are an invaluable asset. They empower scientists to unravel the complexities of signal transduction pathways, deliver accurate functional assessments, and ultimately contribute to the advancement of biomedical research.

With a strong commitment to scientific excellence, our company specializes in developing high-quality biological products designed to meet the needs of cutting-edge research. We pride ourselves on our innovative approaches and dedication to supporting the scientific community's pursuit of knowledge and breakthroughs.

Please note that all services are for research use only. Not intended for any clinical use.

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