Gene: DOC2A
Official Full Name: double C2 domain alphaprovided by HGNC
Gene Summary: There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO34155 | DOC2A Knockout cell line (HCT 116) | Human | DOC2A | 1:2~1:4 | Negative | Online Inquiry |
KO34156 | DOC2A Knockout cell line (HEK293) | Human | DOC2A | 1:3~1:6 | Negative | Online Inquiry |
KO34157 | DOC2A Knockout cell line (A549) | Human | DOC2A | 1:3~1:4 | Negative | Online Inquiry |
DOC2A Gene Knockout Cell Lines represent a significant advancement in the field of genetic research and functional genomics. These cell lines have been meticulously engineered to lack functional DOC2A protein, allowing for precise studies of the gene's effects on cellular processes. This knockout model serves as a powerful tool for elucidating the role of DOC2A in cellular signaling pathways, neurotransmitter release, and other vital biological mechanisms.
The primary function of the DOC2A Knockout Cell Lines lies in their ability to facilitate targeted investigations into the gene's contributions to various physiological and pathological conditions. By observing the differences in cell behavior and function in the absence of DOC2A, researchers can uncover novel insights into its role in neurobiology, including synaptic transmission and plasticity. The mechanism behind these knockout lines involves CRISPR-Cas9 gene editing technology, which ensures a high level of specificity and efficiency in gene disruption, thereby minimizing off-target effects.
Scientifically, the importance of these cell lines is underscored by their wide-ranging applications in both research and clinical settings. They provide researchers with a reliable model for studying the implications of DOC2A dysregulation in diseases such as schizophrenia, neurodegeneration, and other neuropsychiatric disorders. Furthermore, the use of these knockout models can accelerate the drug discovery process by yielding valuable data on potential therapeutic targets related to DOC2A.
What sets DOC2A Gene Knockout Cell Lines apart from alternative models is their robustness and the comprehensive background data that accompanies them, which includes the characterization of cellular phenotypes and functional assays. This level of detailed profiling is crucial for researchers looking to draw clear and actionable conclusions from their studies.
For researchers, clinicians, and pharmaceutical companies, the true value of DOC2A Gene Knockout Cell Lines lies in their ability to enhance experimental reproducibility and depth of understanding. By utilizing these specialized tools, users can drive forward their research with confidence, directly impacting the development of new therapeutic approaches.
Our company prides itself on offering leading-edge biological products, backed by extensive expertise in genetic engineering and a commitment to supporting the research community with high-quality, reliable models. With our DOC2A Gene Knockout Cell Lines, you can count on advanced tools that drive innovation in your research endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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