Gene: DNPH1
Official Full Name: 2'-deoxynucleoside 5'-phosphate N-hydrolase 1provided by HGNC
Gene Summary: This gene was identified on the basis of its stimulation by c-Myc protein. The latter is a transcription factor that participates in the regulation of cell proliferation, differentiation, and apoptosis. The exact function of this gene is not known but studies in rat suggest a role in cellular proliferation and c-Myc-mediated transformation. Two alternative transcripts encoding different proteins have been described. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO31688 | DNPH1 Knockout cell line (HeLa) | Human | DNPH1 | 1:3~1:6 | Negative | Online Inquiry |
KO31689 | DNPH1 Knockout cell line (HCT 116) | Human | DNPH1 | 1:2~1:4 | Negative | Online Inquiry |
KO31690 | DNPH1 Knockout cell line (HEK293) | Human | DNPH1 | 1:3~1:6 | Negative | Online Inquiry |
KO31691 | DNPH1 Knockout cell line (A549) | Human | DNPH1 | 1:3~1:4 | Negative | Online Inquiry |
DNPH1 Gene Knockout Cell Lines are meticulously engineered cellular systems designed to facilitate detailed studies of the DNPH1 gene's functions and its role in various biological processes. By utilizing CRISPR-Cas9 gene-editing technology to selectively disrupt the DNPH1 gene, these cell lines provide researchers with an invaluable tool for elucidating the gene’s contributions to cellular metabolism, response to oxidative stress, and potential roles in disease pathogenesis.
The primary mechanism underlying the utility of DNPH1 Gene Knockout Cell Lines lies in their ability to enable targeted investigation into the gene's functional pathways. These knockout models allow for comparative analyses between wild-type and gene-disrupted cellular phenotypes, thereby clarifying the downstream effects of DNPH1 loss. Researchers can assess alterations in cellular behaviors such as proliferation, apoptosis, and metabolic changes, providing insights that are critical for understanding disorders linked to oxidative stress, including cancer and neurodegenerative diseases.
The scientific importance of these cell lines extends into both research and clinical environments. In laboratories, they serve as a platform for drug discovery and the development of therapeutic approaches aimed at modulating DNPH1 activity. Clinically, insights derived from studies using DNPH1 knockout cells can inform strategies for biomarker discovery and therapeutic targets.
What differentiates DNPH1 Gene Knockout Cell Lines from standard cell models is their precision and specificity, offering a more profound understanding of gene function with more accurate translational relevance. Unlike traditional knockout models that may exhibit off-target effects, these cells provide confidence in experimental outcomes due to their precise gene modification.
For researchers and clinicians seeking rigorous models of gene function, DNPH1 Gene Knockout Cell Lines represent a pivotal asset, enabling high-throughput screening and mechanistic studies essential for novel therapeutic advancements. With our company's proven expertise in genetic engineering and commitment to quality, we ensure that our customers have access to reliably characterized and validated products that propel their research forward.
Please note that all services are for research use only. Not intended for any clinical use.
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