Gene: DNAJB2
Official Full Name: DnaJ heat shock protein family (Hsp40) member B2provided by HGNC
Gene Summary: This gene is almost exclusively expressed in the brain, mainly in the neuronal layers. It encodes a protein that shows sequence similarity to bacterial DnaJ protein and the yeast homologs. In bacteria, this protein is implicated in protein folding and protein complex dissociation. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO37161 | DNAJB2 Knockout cell line (HeLa) | Human | DNAJB2 | 1:3~1:6 | Negative | Online Inquiry |
KO37162 | DNAJB2 Knockout cell line (HCT 116) | Human | DNAJB2 | 1:2~1:4 | Negative | Online Inquiry |
KO37163 | DNAJB2 Knockout cell line (HEK293) | Human | DNAJB2 | 1:3~1:6 | Negative | Online Inquiry |
KO37164 | DNAJB2 Knockout cell line (A549) | Human | DNAJB2 | 1:3~1:4 | Negative | Online Inquiry |
DNAJB2 Gene Knockout Cell Lines represent a pivotal advancement in the study of molecular biology and gene function. These cell lines have been meticulously engineered to disable the DNAJB2 gene, which is integral to the regulation of protein folding and cellular stress responses. By eliminating this gene, researchers can explore its contributions to various biological processes and diseases, particularly in understanding the mechanisms underlying protein misfolding disorders, neurodegenerative diseases, and certain cancers.
The key function of these knockout cell lines lies in their ability to serve as a controlled environment for studying the absence of DNAJB2. Researchers can observe cellular behavior and stress response pathways in isolation, shedding light on the role of DNAJB2 in protein homeostasis and cell survival. This mechanism facilitates a comparative analysis with wild-type cells, enhancing our understanding of how the loss of DNAJB2 may influence cellular function and contribute to disease pathology.
In both research and clinical settings, these cell lines offer significant scientific value. They can be utilized in drug screening, gene therapy research, and as models for understanding how alterations in chaperone proteins affect cellular health. Their application can lead to novel therapeutic strategies targeting related diseases, thus advancing the field of precision medicine.
What sets our DNAJB2 Gene Knockout Cell Lines apart is their validated performance, reproducibility, and comprehensive support provided by our team of experts. Compared to other model systems, these cell lines provide a unique advantage by enabling targeted studies without the confounding influences present in in vivo systems. Furthermore, our knockout cell lines are developed with high specificity and rigorous quality controls, ensuring that researchers work with reliable and robust tools.
For researchers and clinicians committed to advancing our understanding of genetic influences on health and disease, employing these knockout cell lines provides a pathway to uncover innovative insights and therapeutic potentials. Our company is dedicated to supporting scientific discovery, backed by years of expertise in developing high-quality biological products tailored to the needs of the research community.
Please note that all services are for research use only. Not intended for any clinical use.
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