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DNAAF3 Knockout Cell Lines

Gene: DNAAF3

Official Full Name: dynein axonemal assembly factor 3provided by HGNC

Gene Summary: The protein encoded by this gene is required for the assembly of axonemal inner and outer dynein arms and plays a role in assembling dynein complexes for transport into cilia. Defects in this gene are a cause of primary ciliary dyskinesia type 2 (CILD2). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO18260 DNAAF3 Knockout cell line (HeLa) Human DNAAF3 1:3~1:6 Negative Online Inquiry
KO18261 DNAAF3 Knockout cell line (HCT 116) Human DNAAF3 1:2~1:4 Negative Online Inquiry
KO18262 DNAAF3 Knockout cell line (HEK293) Human DNAAF3 1:3~1:6 Negative Online Inquiry
KO18263 DNAAF3 Knockout cell line (A549) Human DNAAF3 1:3~1:4 Negative Online Inquiry

Background

DNAAF3 Gene Knockout Cell Lines are precision-engineered cellular models that lack the expression of the DNAAF3 gene, a critical player in the assembly and function of cilia and flagella in various eukaryotic cells. This unique product is developed through advanced CRISPR-Cas9 technology, effectively knocking out the DNAAF3 gene to enable researchers to explore the biological roles of this gene in cellular motility, signaling pathways, and its implications in diseases related to ciliary dysfunction.

The primary function of these cell lines is to provide a reliable platform for investigating the mechanistic aspects of DNAAF3's role in respiratory health, reproductive biology, and developmental processes. By observing the phenotypic and physiological changes in these knockout models, scientists can elucidate the gene's function and its involvement in pathologies such as primary ciliary dyskinesia and infertility. The cell lines enable high-throughput screening and functional assays that facilitate drug discovery and therapeutic research targeting ciliary-related disorders.

The scientific importance of DNAAF3 Gene Knockout Cell Lines extends to various research domains, including genetics, molecular biology, and translational medicine. Their application in both basic and applied research makes them invaluable for elucidating underlying mechanisms of disease, ultimately paving the way for novel treatment strategies.

Compared to traditional cell lines or less specific knockout models, these cell lines offer enhanced specificity and reproducibility, significantly reducing experimental variability. The use of CRISPR technology further ensures the precision of the knockout, providing researchers with a pure model that accurately reflects the absence of DNAAF3, free from off-target effects.

Researchers, clinicians, and biopharmaceutical companies can leverage the DNAAF3 Gene Knockout Cell Lines to advance their understanding of ciliary biology, leading to breakthroughs in diagnostics and therapeutics. The high-quality and rigorously validated nature of this product reinforces its appeal to the scientific community.

At [Company Name], we pride ourselves on our expertise in genetic engineering and commitment to providing top-tier biological products. Our offerings prioritize innovation and quality to meet the evolving needs of research and clinical applications, ensuring that you have the tools necessary to propel your scientific inquiries forward.

Please note that all services are for research use only. Not intended for any clinical use.

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