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DLG3 Knockout Cell Lines

Gene: DLG3

Official Full Name: discs large MAGUK scaffold protein 3provided by HGNC

Gene Summary: This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked cognitive disability. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO08540 DLG3 Knockout cell line (HeLa) Human DLG3 1:3~1:6 Negative Online Inquiry
KO08541 DLG3 Knockout cell line (HCT 116) Human DLG3 1:2~1:4 Negative Online Inquiry
KO08542 DLG3 Knockout cell line (HEK293) Human DLG3 1:3~1:6 Negative Online Inquiry
KO08543 DLG3 Knockout cell line (A549) Human DLG3 1:3~1:4 Negative Online Inquiry

Background

DLG3 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to disrupt the expression of the DLG3 gene, which encodes a crucial protein involved in synaptic signaling and neurodevelopment. This innovative tool allows researchers to study the functional implications of DLG3 deficiency in various biological contexts, particularly in relation to synaptic plasticity, cognitive functions, and neurological disorders.

The primary mechanism of the DLG3 Gene Knockout Cell Lines involves CRISPR-Cas9 technology, which enables precise editing of the genomic sequence to create loss-of-function mutations. By systematically disabling the DLG3 gene, these cell lines serve as invaluable models for investigating the biological pathways and molecular mechanisms where DLG3 plays a pivotal role. Researchers can explore how this gene impacts cellular communication and synaptic integrity, thereby elucidating its involvement in conditions such as intellectual disabilities and neurodegenerative diseases.

The scientific importance of DLG3 Gene Knockout Cell Lines extends to their application in both fundamental research and clinical settings. These models significantly enhance our understanding of synaptic health and neuronal function, providing a robust platform for drug screening, biomarker discovery, and exploring therapeutic interventions for neurological impairments linked to DLG3.

In comparison to other gene editing methods, our DLG3 Gene Knockout Cell Lines offer unique advantages such as simplicity of use, reproducibility, and the ability for researchers to rapidly generate consistent and high-quality data. This makes them a preferable choice for labs looking to efficiently study gene functions without the complexities associated with traditional knockout models.

For researchers and clinicians focused on unraveling the intricate biology of synapses and associated pathologies, these cell lines are a fundamental resource that bridges basic research and clinical applications. Our company specializes in advanced genetic tools, ensuring that our products, including the DLG3 Gene Knockout Cell Lines, are developed with the highest standards of quality and scientific merit to empower groundbreaking discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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