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DIS3L2 Knockout Cell Lines

Gene: DIS3L2

Official Full Name: DIS3 like 3'-5' exoribonuclease 2provided by HGNC

Gene Summary: The protein encoded by this gene is similar in sequence to 3'/5' exonucleolytic subunits of the RNA exosome. The exosome is a large multimeric ribonucleotide complex responsible for degrading various RNA substrates. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Mar 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO26666 DIS3L2 Knockout cell line (HeLa) Human DIS3L2 1:3~1:6 Negative Online Inquiry
KO26667 DIS3L2 Knockout cell line (HCT 116) Human DIS3L2 1:2~1:4 Negative Online Inquiry
KO26668 DIS3L2 Knockout cell line (HEK293) Human DIS3L2 1:3~1:6 Negative Online Inquiry
KO26669 DIS3L2 Knockout cell line (A549) Human DIS3L2 1:3~1:4 Negative Online Inquiry

Background

DIS3L2 Gene Knockout Cell Lines are specialized tools developed to investigate the biological role of the DIS3L2 gene, which encodes a ribonuclease involved in the regulation of RNA metabolism and degradation. These cell lines are genetically engineered to disrupt the function of the DIS3L2 gene, allowing researchers to study the downstream effects of its knockout on cellular processes and signaling pathways.

The primary function of DIS3L2 is in the control of RNA turnover, ensuring the proper degradation of unneeded or faulty RNA molecules. By utilizing DIS3L2 gene knockout cell lines, scientists can elucidate its role in various cellular contexts, including cell survival, proliferation, and response to stress. The absence of functional DIS3L2 facilitates in-depth studies into disease mechanisms that involve dysregulated RNA metabolism, such as certain cancers and genetic disorders.

The scientific importance of these knockout cell lines lies in their ability to act as a model to test hypotheses related to RNA metabolism and its implications in pathology. In research and clinical settings, they provide invaluable insights into the roles of DIS3L2 in cellular homeostasis and disease progression, making them essential for both basic research and potential therapeutic development.

Compared to traditional methods of gene editing, our DIS3L2 gene knockout cell lines offer a streamlined and efficient approach, ensuring reproducibility and specificity in research outcomes. Furthermore, the established nature of these cell lines allows for immediate application in experimental workflows, reducing the time typically needed for gene editing on-site.

For researchers and clinicians focused on molecular biology and genetic diseases, these knockout cell lines offer a robust framework to unlock the complexities of RNA regulation and its impact on health. The integration of cutting-edge gene editing technologies and extensive support from our company, with years of expertise in developing biological products, ensures users have access to high-quality tools that can significantly enhance their research capabilities.

Please note that all services are for research use only. Not intended for any clinical use.

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