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DHRS3 Knockout Cell Lines

Gene: DHRS3

Official Full Name: dehydrogenase/reductase 3provided by HGNC

Gene Summary: Predicted to enable all-trans-retinol dehydrogenase (NAD+) activity. Predicted to be involved in regulation of retinoic acid receptor signaling pathway and retinoid metabolic process. Predicted to act upstream of or within several processes, including heart morphogenesis; negative regulation of retinoic acid receptor signaling pathway; and regulation of ossification. Predicted to be located in endoplasmic reticulum membrane and photoreceptor outer segment membrane. Predicted to be active in lipid droplet. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33410 DHRS3 Knockout cell line (HeLa) Human DHRS3 1:3~1:6 Negative Online Inquiry
KO33411 DHRS3 Knockout cell line (HCT 116) Human DHRS3 1:2~1:4 Negative Online Inquiry
KO33412 DHRS3 Knockout cell line (HEK293) Human DHRS3 1:3~1:6 Negative Online Inquiry
KO33413 DHRS3 Knockout cell line (A549) Human DHRS3 1:3~1:4 Negative Online Inquiry

Background

DHRS3 Gene Knockout Cell Lines are engineered cellular models characterized by the targeted deletion of the DHRS3 gene, which plays a significant role in the metabolism of retinoids and steroid hormones. This product allows researchers to investigate the functional consequences of DHRS3 deletion on cellular processes, signaling pathways, and metabolic regulation. By creating a cell line that lacks this specific gene, scientists can better understand its involvement in physiological processes and disease mechanisms.

The primary functionality of DHRS3 Gene Knockout Cell Lines lies in their ability to model the specific biological effects that arise from the absence of DHRS3. This knockout facilitates the exploration of its role in retinol metabolism and may reveal critical insights into fertility, embryonic development, and metabolic disorders. Scientists can utilize these cell lines to study gene function, validate drug targets, and explore interactions within signaling networks, thereby enhancing our understanding of various pathophysiological conditions.

From a scientific perspective, the availability of DHRS3 Gene Knockout Cell Lines is a significant advancement in the field of molecular biology and pharmacogenomics. These models are vital for elucidating the complex roles that DHRS3 may play in human health and disease, paving the way for clinical innovations and therapeutic strategies targeting retinol-related pathways.

A key advantage of DHRS3 Gene Knockout Cell Lines is their specificity and reliability compared to alternative methods such as transient transfection or chemical inhibition, which can yield variable results. These stable knockout cell lines offer high reproducibility and can be easily integrated into a wide array of experimental setups, signaling a robust approach for studying gene function in various contexts.

For researchers and clinicians, investing in DHRS3 Gene Knockout Cell Lines presents an invaluable opportunity to advance their studies in genetic regulation, metabolic pathways, and potential therapeutic interventions. Our company’s expertise in the development of high-quality biological products ensures that these cell lines are produced with precision and care, providing a solid foundation for groundbreaking research and innovation. We are committed to supporting the scientific community with genetically modified models that enhance the exploration and understanding of critical biological functions.

Please note that all services are for research use only. Not intended for any clinical use.

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