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DHRS2 Knockout Cell Lines

Gene: DHRS2

Official Full Name: dehydrogenase/reductase 2provided by HGNC

Gene Summary: This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members of this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. Alternative promoter use and alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO32159 DHRS2 Knockout cell line (HCT 116) Human DHRS2 1:2~1:4 Negative Online Inquiry
KO32160 DHRS2 Knockout cell line (HEK293) Human DHRS2 1:3~1:6 Negative Online Inquiry
KO32161 DHRS2 Knockout cell line (A549) Human DHRS2 1:3~1:4 Negative Online Inquiry

Background

DHRS2 Gene Knockout Cell Lines are sophisticated biological products designed for the study of the dHADH-related short-chain dehydrogenase/reductase 2 (DHRS2) gene, which plays a pivotal role in various metabolic pathways. These engineered cell lines have been specifically developed to facilitate the investigation of the functional consequences of DHRS2 gene disruption, enabling researchers to explore its involvement in disease states and metabolic dysfunctions.

The key function of these knockout cell lines lies in their ability to allow scientists to assess the impact of the absence of the DHRS2 gene on cellular metabolism and signaling pathways. This is achieved through methods such as CRISPR/Cas9 gene-editing technology, which provides a precise and efficient means of gene targeting. By comparing the biological characteristics of DHRS2 knockout cells with wild-type controls, researchers can elucidate the gene's physiological roles and its potential contributions to pathophysiological conditions, such as cancer metabolism and cardiovascular diseases.

The scientific importance of DHRS2 Gene Knockout Cell Lines is underscored by their wide-ranging applications in both basic and translational research settings. These cell lines serve as invaluable tools for drug discovery, functional genomics, and therapeutic development, providing insights that could lead to novel targeted therapies. Moreover, their use can significantly reduce the time and costs associated with developing new therapeutic strategies aimed at diseases linked to metabolic dysregulation.

One of the primary advantages of utilizing DHRS2 Gene Knockout Cell Lines over traditional models is their specificity and reproducibility. Unlike standard knockout mice, which can be resource-intensive and time-consuming to develop, these cell lines can be readily generated and maintained in vitro, providing a more accessible and efficient experimental platform. Furthermore, they are compatible with high-throughput screening technologies, allowing for rapid evaluation of pharmacological agents or genetic enhancers.

Ultimately, the value of DHRS2 Gene Knockout Cell Lines extends beyond their technical offerings; they empower researchers and clinicians with the insights necessary for advancing scientific knowledge and improving patient outcomes. Emphasizing our commitment to quality and innovation, our company strives to provide cutting-edge biological products that facilitate groundbreaking research and support the development of new therapeutic approaches.

Please note that all services are for research use only. Not intended for any clinical use.

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