Gene: DGKQ
Official Full Name: diacylglycerol kinase thetaprovided by HGNC
Gene Summary: The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00958 | DGKQ Knockout cell line(Hep G2) | Human | DGKQ | 1:2~1:4 | Negative | Online Inquiry |
KO07762 | DGKQ Knockout cell line (HeLa) | Human | DGKQ | 1:3~1:6 | Negative | Online Inquiry |
KO07763 | DGKQ Knockout cell line (HCT 116) | Human | DGKQ | 1:2~1:4 | Negative | Online Inquiry |
KO07764 | DGKQ Knockout cell line (HEK293) | Human | DGKQ | 1:3~1:6 | Negative | Online Inquiry |
KO07765 | DGKQ Knockout cell line (A549) | Human | DGKQ | 1:3~1:4 | Negative | Online Inquiry |
DGKQ Gene Knockout Cell Lines consist of genetically modified cell lines in which the DGKQ gene has been disrupted or 'knocked out' using advanced gene-editing technologies such as CRISPR-Cas9. These cell lines serve as a crucial tool for studying the functional role of the DGKQ protein in various biological processes, including cell signaling, metabolism, and proliferation. By creating a controlled environment where the expression of DGKQ is nullified, researchers can observe alterations in cellular behavior, providing insights into the gene's role in health and disease.
The primary mechanism by which DGKQ knockout cell lines operate involves the complete loss of DGKQ protein function, which subsequently affects pathways influenced by diacylglycerol levels in the cell. This disruption allows scientists to investigate mechanisms underlying conditions such as cancer, cardiovascular disease, and neurological disorders, as DGKQ is implicated in various signaling cascades. Researchers can employ these cell lines in protein interaction studies, drug testing, and to better understand disease mechanisms, making them invaluable for research and therapeutic development.
Compared to traditional models, DGKQ gene knockout cell lines offer several unique advantages. They provide a more precise genetic manipulation than conventional methods, reducing background noise from unrelated gene activities. Additionally, these cell lines can be easily cultured and manipulated, facilitating high-throughput experiments. Unlike alternative systems, such as whole animal models, these cell lines allow for controlled experimentation where conditions can be precisely monitored.
For researchers and clinicians, the value of DGKQ Gene Knockout Cell Lines lies in their ability to contribute to a deeper understanding of gene function and its implications in disease. This could lead to the development of novel therapeutic strategies and enhanced disease models.
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Please note that all services are for research use only. Not intended for any clinical use.
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