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DGKQ Knockout Cell Lines

Gene: DGKQ

Official Full Name: diacylglycerol kinase thetaprovided by HGNC

Gene Summary: The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00958 DGKQ Knockout cell line(Hep G2) Human DGKQ 1:2~1:4 Negative Online Inquiry
KO07762 DGKQ Knockout cell line (HeLa) Human DGKQ 1:3~1:6 Negative Online Inquiry
KO07763 DGKQ Knockout cell line (HCT 116) Human DGKQ 1:2~1:4 Negative Online Inquiry
KO07764 DGKQ Knockout cell line (HEK293) Human DGKQ 1:3~1:6 Negative Online Inquiry
KO07765 DGKQ Knockout cell line (A549) Human DGKQ 1:3~1:4 Negative Online Inquiry

Background

DGKQ Gene Knockout Cell Lines consist of genetically modified cell lines in which the DGKQ gene has been disrupted or 'knocked out' using advanced gene-editing technologies such as CRISPR-Cas9. These cell lines serve as a crucial tool for studying the functional role of the DGKQ protein in various biological processes, including cell signaling, metabolism, and proliferation. By creating a controlled environment where the expression of DGKQ is nullified, researchers can observe alterations in cellular behavior, providing insights into the gene's role in health and disease.

The primary mechanism by which DGKQ knockout cell lines operate involves the complete loss of DGKQ protein function, which subsequently affects pathways influenced by diacylglycerol levels in the cell. This disruption allows scientists to investigate mechanisms underlying conditions such as cancer, cardiovascular disease, and neurological disorders, as DGKQ is implicated in various signaling cascades. Researchers can employ these cell lines in protein interaction studies, drug testing, and to better understand disease mechanisms, making them invaluable for research and therapeutic development.

Compared to traditional models, DGKQ gene knockout cell lines offer several unique advantages. They provide a more precise genetic manipulation than conventional methods, reducing background noise from unrelated gene activities. Additionally, these cell lines can be easily cultured and manipulated, facilitating high-throughput experiments. Unlike alternative systems, such as whole animal models, these cell lines allow for controlled experimentation where conditions can be precisely monitored.

For researchers and clinicians, the value of DGKQ Gene Knockout Cell Lines lies in their ability to contribute to a deeper understanding of gene function and its implications in disease. This could lead to the development of novel therapeutic strategies and enhanced disease models.

Our company specializes in cutting-edge genetic tools and offerings, ensuring that our products are backed by rigorous scientific validation and are positioned to meet the evolving needs of researchers and clinicians in the field of molecular biology.

Please note that all services are for research use only. Not intended for any clinical use.

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