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DDX60L Knockout Cell Lines

Gene: DDX60L

Official Full Name: DExD/H-box 60 likeprovided by HGNC

Gene Summary: This gene encodes a member of the DExD/H-box helicase family of proteins, a subset of the super family 2 helicases. Members of the DExD/H-box helicase family share a conserved functional core comprised of two RecA-like globular domains. These domains contain conserved motifs that mediate ATP binding, ATP hydrolysis, nucleic acid binding, and RNA unwinding. In addition to functions in RNA metabolism, members of this family are involved in anti-viral immunity and act as cytosolic sensors of viral nucleic acids. The protein encoded by this gene has been shown to inhibit hepatitis C virus replication in response to interferon stimulation in cell culture. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO06933 DDX60L Knockout cell line (HeLa) Human DDX60L 1:3~1:6 Negative Online Inquiry
KO06934 DDX60L Knockout cell line (HCT 116) Human DDX60L 1:2~1:4 Negative Online Inquiry
KO06935 DDX60L Knockout cell line (HEK293) Human DDX60L 1:3~1:6 Negative Online Inquiry
KO06936 DDX60L Knockout cell line (A549) Human DDX60L 1:3~1:4 Negative Online Inquiry

Background

DDX60L Gene Knockout Cell Lines are a cutting-edge biological tool designed to enhance research in gene function, disease modeling, and therapeutic development. These cell lines are genetically engineered to have the DDX60L gene disrupted, thereby providing a versatile system for studying the consequences of DDX60L loss on cellular processes, signaling pathways, and phenotypic characteristics. The DDX60L protein is implicated in critical immune responses and antiviral activities, positioning these knockout cell lines as essential models for understanding its role in various biological systems.

The primary function of DDX60L Gene Knockout Cell Lines lies in their ability to facilitate the investigation of the DDX60-like helicase's role in innate immunity and RNA metabolism. By utilizing CRISPR-Cas9 technology, these cell lines exhibit precise gene knockout, allowing researchers to elucidate the mechanistic pathways that govern immune responses to viral infections. The knockout models enable scientists to perform loss-of-function studies, aiding in the identification of potential drug targets and helping to unravel complex molecular interactions.

The scientific importance of DDX60L Gene Knockout Cell Lines is profound, particularly in the context of infectious diseases, cancer research, and immunology. Applications in research can range from basic science to translational studies aimed at developing targeted therapies. Their unique characteristics facilitate the establishment of robust in vitro systems that mirror in vivo conditions, thereby accelerating the discovery of therapeutic interventions.

Compared to alternative models, DDX60L Gene Knockout Cell Lines provide unparalleled specificity and gain-of-function options with minimal off-target effects, ensuring that researchers obtain accurate and reproducible results. Moreover, they are available in a variety of host cell backgrounds, enabling adaptation to multiple experimental needs.

For researchers and clinicians, the value of utilizing DDX60L Gene Knockout Cell Lines is immense; they not only provide clarity in complex biological pathways but also represent a significant step towards novel therapeutic approaches. By leveraging these advanced genetic models, users can enhance the quality and impact of their research findings.

At our company, we are leaders in providing innovative biological products and advanced cell line technologies. With a commitment to scientific excellence, we equip researchers with the tools necessary for groundbreaking discoveries and advancements in healthcare.

Please note that all services are for research use only. Not intended for any clinical use.

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