Home / DCLK2 Knockout Cell Lines

DCLK2 Knockout Cell Lines

Gene: DCLK2

Official Full Name: doublecortin like kinase 2provided by HGNC

Gene Summary: This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Sep 2010]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO18379 DCLK2 Knockout cell line (HeLa) Human DCLK2 1:3~1:6 Negative Online Inquiry
KO18380 DCLK2 Knockout cell line (HCT 116) Human DCLK2 1:2~1:4 Negative Online Inquiry
KO18381 DCLK2 Knockout cell line (HEK293) Human DCLK2 1:3~1:6 Negative Online Inquiry
KO18382 DCLK2 Knockout cell line (A549) Human DCLK2 1:3~1:4 Negative Online Inquiry

Background

DCLK2 Gene Knockout Cell Lines are genetically engineered cellular models that specifically lack the expression of the doublecortin-like kinase 2 (DCLK2) gene. This gene has been implicated in various cellular processes, including neurogenesis and cancer progression. The generation of knockout cell lines allows researchers to study the phenotypic and molecular consequences of DCLK2 deficiency, providing insights into its role in both normal physiological functions and pathological conditions.

The key function of DCLK2 Gene Knockout Cell Lines lies in their utilization for experimental studies focused on understanding signaling pathways and biological mechanisms associated with DCLK2. By providing a controlled environment devoid of DCLK2, scientists can explore how the absence of this kinase influences cellular behaviors such as proliferation, differentiation, and apoptosis. These lines can also serve as valuable tools in drug screening and therapeutic development, particularly in cancer research, where DCLK2 is a potential biomarker and therapeutic target.

The scientific importance of DCLK2 Gene Knockout Cell Lines is underlined by their applications in both basic and translational research. They are critical for elucidating the molecular cascades that govern neurodevelopment and tumor biology, making them invaluable in the search for new therapeutic strategies.

One of the unique selling points of these knockout cell lines is their precision in targeting the DCLK2 gene, which is often more effective compared to broad-spectrum inhibitors that may affect multiple pathways. This specificity minimizes off-target effects, allowing for clearer interpretations of experimental data.

For researchers and clinicians, the ability to use DCLK2 Gene Knockout Cell Lines translates into a robust platform for investigating gene function and developing targeted therapies, particularly in neuro-oncology or neurological disorders. These models can accelerate discoveries that contribute to improved patient outcomes.

Our company specializes in developing advanced genetic models and cell lines, and we are committed to providing high-quality, reproducible products that empower the scientific community to advance biological and medical research. With our expertise in genetic engineering, we ensure that our DCLK2 Gene Knockout Cell Lines meet the rigorous demands of today’s research landscape.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.