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Ccl5 Knockout Cell Lines

Gene: Ccl5

Official Full Name: C-C motif chemokine ligand 5provided by MGI

Gene Summary: Enables CCR1 chemokine receptor binding activity. Involved in negative regulation of macrophage apoptotic process and positive regulation of monocyte chemotaxis. Acts upstream of or within inflammatory response; positive regulation of epithelial cell proliferation; and response to tumor necrosis factor. Located in cytoplasm and extracellular space. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; liver; and retina. Human ortholog(s) of this gene implicated in several diseases, including hepatitis B; hepatitis C; liver disease (multiple); pulmonary tuberculosis; and severe acute respiratory syndrome. Orthologous to human CCL5 (C-C motif chemokine ligand 5). [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01078 Ccl5 Knockout cell line (EO771) Mouse Ccl5 1:2-1:4 Negative Online Inquiry

Background

Ccl5 Gene Knockout Cell Lines are genetically engineered cell lines in which the Ccl5 gene, also known as RANTES (Regulated upon Activation, Normal T Expressed and Secreted), has been effectively disrupted, providing a valuable tool for investigating the role of this chemokine in various biological processes. Ccl5 is involved in the recruitment and activation of immune cells, particularly during inflammatory responses, making these knockout cell lines essential for examining the mechanistic roles of Ccl5 in both health and disease contexts.

The primary function of these cell lines is to enable researchers to assess the effects of the absence of Ccl5 on cellular communication, immune responses, and disease progression. By utilizing these knockout models, scientists can explore alternate signaling pathways and compensatory mechanisms that may arise when Ccl5 is not expressed, thereby deepening our understanding of immune system dynamics and interactions.

The scientific importance of Ccl5 Gene Knockout Cell Lines is underscored by their applications in cancer research, autoimmune disease studies, and viral infection models. They provide a platform for elucidating how Ccl5-mediated signaling influences tumor microenvironments or contributes to the pathogenesis of various diseases, making them applicable in both basic and translational research settings.

Compared to conventional or knockdown models, Ccl5 Gene Knockout Cell Lines offer unparalleled specificity and reliability, ensuring that researchers can draw robust conclusions about the direct effects of Ccl5 deletion without confounding interactions from partial inhibition.

For researchers and clinicians, the value of Ccl5 Gene Knockout Cell Lines lies in their ability to accelerate the discovery of new therapeutic strategies targeting inflammatory processes and immune-related conditions. Their precise genetic modification allows for reproducible results that bolster the rigor of research findings.

Our company is committed to advancing scientific understanding through our innovative biological products, ensuring that we provide top-tier tools like Ccl5 Gene Knockout Cell Lines that empower researchers to unravel the complexities of cellular signaling and host responses in various health scenarios.

Please note that all services are for research use only. Not intended for any clinical use.

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