Gene: CYB5R3
Official Full Name: cytochrome b5 reductase 3provided by HGNC
Gene Summary: This gene encodes cytochrome b5 reductase, which includes a membrane-bound form in somatic cells (anchored in the endoplasmic reticulum, mitochondrial and other membranes) and a soluble form in erythrocytes. The membrane-bound form exists mainly on the cytoplasmic side of the endoplasmic reticulum and functions in desaturation and elongation of fatty acids, in cholesterol biosynthesis, and in drug metabolism. The erythrocyte form is located in a soluble fraction of circulating erythrocytes and is involved in methemoglobin reduction. The membrane-bound form has both membrane-binding and catalytic domains, while the soluble form has only the catalytic domain. Alternate splicing results in multiple transcript variants. Mutations in this gene cause methemoglobinemias. [provided by RefSeq, Jan 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38247 | CYB5R3 Knockout cell line (HeLa) | Human | CYB5R3 | 1:3~1:6 | Negative | Online Inquiry |
KO38248 | CYB5R3 Knockout cell line (HCT 116) | Human | CYB5R3 | 1:2~1:4 | Negative | Online Inquiry |
KO38249 | CYB5R3 Knockout cell line (HEK293) | Human | CYB5R3 | 1:3~1:6 | Negative | Online Inquiry |
KO38250 | CYB5R3 Knockout cell line (A549) | Human | CYB5R3 | 1:3~1:4 | Negative | Online Inquiry |
CYB5R3 Gene Knockout Cell Lines represent a sophisticated tool designed for research involving the cytochrome b5 reductase 3 (CYB5R3) gene, an important player in cellular redox reactions and lipid metabolism. These cell lines have been genetically modified to inactivate the CYB5R3 gene, allowing researchers to investigate the physiological and pathological consequences of reduced CYB5R3 expression in a controlled environment.
The key functions of these knockout cell lines stem from the loss of CYB5R3, which is central to facilitating electron transfer in metabolic processes and cellular signaling. By studying these cell lines, researchers can elucidate the role of CYB5R3 in various biological functions, including but not limited to drug metabolism, oxidative stress response, and lipid homeostasis. The capability to better understand these mechanisms has significant implications for both basic research and therapeutic development.
In clinical and research settings, CYB5R3 Gene Knockout Cell Lines serve as an invaluable resource for advancing knowledge in homeostatic regulation, disease modeling, and pharmacological research. They enable a more profound understanding of metabolic disorders and may help identify novel therapeutic targets for conditions like diabetes, obesity, and cardiovascular diseases.
Compared to alternatives, such as wild-type cell lines or transient knockdown approaches, these stable knockout cell lines offer advantages in terms of genetic consistency and reproducibility of experimental results. The permanent disruption of the CYB5R3 gene allows for longitudinal studies and more nuanced insight into cellular behaviors over time.
For researchers and clinicians focused on metabolic pathways and therapeutic innovations, our CYB5R3 Gene Knockout Cell Lines are a powerful asset. They facilitate rigorous experimentation and provide a foundation for pioneering research, ultimately driving advancements in the life sciences. Our company, a leader in producing genetically engineered cell lines, brings expertise and a commitment to quality, ensuring you have the best tools available for your research endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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