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CYB5R2 Knockout Cell Lines

Gene: CYB5R2

Official Full Name: cytochrome b5 reductase 2provided by HGNC

Gene Summary: The protein encoded by this gene belongs to the flavoprotein pyridine nucleotide cytochrome reductase family of proteins. Cytochrome b-type NAD(P)H oxidoreductases are implicated in many processes including cholesterol biosynthesis, fatty acid desaturation and elongation, and respiratory burst in neutrophils and macrophages. Cytochrome b5 reductases have soluble and membrane-bound forms that are the product of alternative splicing. In animal cells, the membrane-bound form binds to the endoplasmic reticulum, where it is a member of a fatty acid desaturation complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO22252 CYB5R2 Knockout cell line (HeLa) Human CYB5R2 1:3~1:6 Negative Online Inquiry
KO22253 CYB5R2 Knockout cell line (HCT 116) Human CYB5R2 1:2~1:4 Negative Online Inquiry
KO22254 CYB5R2 Knockout cell line (A549) Human CYB5R2 1:3~1:4 Negative Online Inquiry

Background

CYB5R2 Gene Knockout Cell Lines are specifically engineered cellular models that lack the cytochrome b5 reductase 2 (CYB5R2) gene, which plays a crucial role in the electron transfer processes of several metabolic pathways. By targeting this gene for knockout, researchers can explore the functional implications of CYB5R2 deficiency on cell function, metabolism, and disease pathways. The mechanism underlying these knockout cell lines involves precise gene editing techniques, such as CRISPR/Cas9, to disrupt the CYB5R2 gene, resulting in a universally applicable tool for studying cytochrome b5 reductase-related reactions and their downstream effects in cellular environments.

The scientific importance of CYB5R2 Gene Knockout Cell Lines is significant, especially in research contexts focusing on metabolic diseases, cancer biology, and pharmacology. These cell lines enable researchers to investigate the role of CYB5R2 in cellular redox reactions, drug metabolism, and oxidative stress responses. Furthermore, the potential for clinical applications extends to understanding drug interactions and their efficacy, wherein the absence of CYB5R2 can provide insights into metabolic variations among individuals.

What sets these cell lines apart is the reliable and reproducible model they offer for functional analyses, combined with comprehensive screening options for pharmaceutical development. Unlike traditional cell lines that may express variable levels of cytochrome b5 reductase, the CYB5R2 knockout cell lines provide a consistent platform for research, enhancing the accuracy of experimental outcomes.

The value of CYB5R2 Gene Knockout Cell Lines to researchers and clinicians lies in their ability to simulate pathological conditions with precision, facilitating targeted investigations that can lead to innovative therapeutic strategies. By utilizing these cell lines, stakeholders can accelerate their research processes and contribute to significant advancements in the understanding of disease mechanisms.

At our company, we pride ourselves on our commitment to advancing biological research through innovative products. Our expertise in genetic engineering and cellular biology ensures that our CYB5R2 Gene Knockout Cell Lines provide researchers with cutting-edge tools to drive meaningful discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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