Gene: CSNK2A3
Official Full Name: casein kinase 2 alpha 3provided by HGNC
Gene Summary: This gene encodes a protein that is highly similar to the casein kinase II alpha protein. Casein kinase II is a serine/threonine protein kinase complex that phosphorylates numerous substrates including casein. The alpha subunit is the catalytic component of the complex. Mutations in this gene may be associated with a susceptibility to lung cancer. There are contradictory views among published reports of this gene as to whether or not it is a protein-coding gene or a processed pseudogene (PMIDs: 20625391, 20625391 and 10094393). [provided by RefSeq, Feb 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO18508 | CSNK2A3 Knockout cell line (HeLa) | Human | CSNK2A3 | 1:3~1:6 | Negative | Online Inquiry |
KO18509 | CSNK2A3 Knockout cell line (HCT 116) | Human | CSNK2A3 | 1:2~1:4 | Negative | Online Inquiry |
KO18510 | CSNK2A3 Knockout cell line (A549) | Human | CSNK2A3 | 1:3~1:4 | Negative | Online Inquiry |
CSNK2A3 Gene Knockout Cell Lines are specialized cellular models designed for the precise study of the casein kinase 2 alpha 3 (CSNK2A3) gene's functions and its role in various biological processes. These knockout cell lines have undergone targeted genome editing, resulting in the complete disruption of the CSNK2A3 gene. This innovative approach allows researchers to investigate the downstream effects of gene loss, contributing to our understanding of its involvement in cellular signaling, proliferation, and differentiation.
The key mechanism underlying these knockout cell lines is CRISPR/Cas9 technology, which enables highly efficient and specific alterations to genomic DNA. Researchers can utilize these knockout models to analyze how the absence of CSNK2A3 affects cellular pathways linked to cancer progression, neurodegeneration, and other diseases. By providing insights into the functional consequences of gene deletion, these cell lines serve as invaluable tools in both basic and applied research settings.
Scientific applications of CSNK2A3 gene knockout cell lines extend to drug discovery, where they can be employed to assess the efficacy of potential therapeutics targeting CSNK2A3-related pathways. Moreover, their use in studying the gene's implications in various tumor types enables the identification of novel biomarkers and therapeutic targets, thereby enhancing clinical relevance.
Compared to traditional wild-type cell lines, CSNK2A3 gene knockout variants provide a unique advantage by allowing for the unambiguous attribution of phenotypic changes to the absence of the CSNK2A3 protein. This specificity strengthens the validity of experimental results and accelerates hypothesis testing in research.
For researchers and clinicians focused on molecular biology and translational medicine, investing in CSNK2A3 gene knockout cell lines offers access to precise models that can lead to groundbreaking discoveries and more effective treatment strategies. Our company, with its extensive expertise in genetic engineering and cell line development, is dedicated to providing high-quality biological products that drive innovation and support scientists worldwide.
Please note that all services are for research use only. Not intended for any clinical use.
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