Gene: CSNK1D
Official Full Name: casein kinase 1 deltaprovided by HGNC
Gene Summary: This gene is a member of the casein kinase I (CKI) gene family whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein may also be involved in the regulation of apoptosis, circadian rhythm, microtubule dynamics, chromosome segregation, and p53-mediated effects on growth. The encoded protein is highly similar to the mouse and rat CK1 delta homologs. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO08528 | CSNK1D Knockout cell line (HeLa) | Human | CSNK1D | 1:3~1:6 | Negative | Online Inquiry |
KO08529 | CSNK1D Knockout cell line (HCT 116) | Human | CSNK1D | 1:2~1:4 | Negative | Online Inquiry |
KO08530 | CSNK1D Knockout cell line (HEK293) | Human | CSNK1D | 1:3~1:6 | Negative | Online Inquiry |
KO08531 | CSNK1D Knockout cell line (A549) | Human | CSNK1D | 1:3~1:4 | Negative | Online Inquiry |
CSNK1D Gene Knockout Cell Lines are genetically modified cell lines where the CSNK1D gene, integral to numerous cellular processes, has been effectively disrupted. This knockout allows researchers to elucidate the role of CSNK1D in cellular signaling pathways and biological functions, particularly in the context of circadian rhythm regulation, cancer biology, and developmental processes. By creating these cell lines, researchers have a powerful tool to dissect the downstream effects of CSNK1D absence, revealing critical insights into its contributions to various physiological and pathological states.
The key function of CSNK1D within cells is its involvement in phosphorylation processes and circadian clock mechanisms. It serves as a regulator of the circadian clock by modifying protein stability and cellular responses to diverse stimuli. The knockout of this gene results in altered circadian rhythms, providing a valuable model for understanding disruptions in biological timing that can lead to sleep disorders or metabolic syndromes.
Scientifically, these CSNK1D Gene Knockout Cell Lines hold critical applications in both research and clinical settings. They can be utilized in drug screening, enabling scientists to identify novel therapeutic targets for diseases influenced by circadian rhythms. Moreover, these cell lines can assist in the study of tumor biology, as aberrations in circadian regulation are often linked to cancer progression.
Compared to other genetic modification methods, CSNK1D knockout cell lines offer a specific and targeted approach, minimizing off-target effects and facilitating more precise scientific inquiries. Their use provides researchers with reproducible and consistent data, which is paramount in validating hypotheses and ensuring translational applicability.
For researchers and clinicians interested in understanding the dual roles of CSNK1D in health and disease, these cell lines represent a critical resource that can enhance comprehension and lead to innovations in treatment strategies. Our company is dedicated to providing high-quality biological products, backed by extensive expertise in genetic engineering and cell line development, ensuring that researchers have access to the tools necessary for advancing scientific knowledge and medical breakthroughs.
Please note that all services are for research use only. Not intended for any clinical use.
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