Gene: CRYZ
Official Full Name: crystallin zetaprovided by HGNC
Gene Summary: Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. The former class is also called phylogenetically-restricted crystallins. This gene encodes a taxon-specific crystallin protein which has NADPH-dependent quinone reductase activity distinct from other known quinone reductases. It lacks alcohol dehydrogenase activity although by similarity it is considered a member of the zinc-containing alcohol dehydrogenase family. Unlike other mammalian species, in humans, lens expression is low. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One pseudogene is known to exist. [provided by RefSeq, Sep 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38402 | CRYZ Knockout cell line (HeLa) | Human | CRYZ | 1:3~1:6 | Negative | Online Inquiry |
KO38403 | CRYZ Knockout cell line (HCT 116) | Human | CRYZ | 1:2~1:4 | Negative | Online Inquiry |
KO38404 | CRYZ Knockout cell line (HEK293) | Human | CRYZ | 1:3~1:6 | Negative | Online Inquiry |
KO38405 | CRYZ Knockout cell line (A549) | Human | CRYZ | 1:3~1:4 | Negative | Online Inquiry |
CRYZ Gene Knockout Cell Lines are customized cell lines specifically engineered to provide a complete knockout of the CRYZ gene, which encodes for the enzyme crystallin zeta. This gene is vital in the study of various biological pathways, particularly those associated with oxidative stress and cellular signaling. By creating these knockout lines, researchers are afforded a powerful tool to elucidate the role of CRYZ in health and disease.
Key functional aspects of CRYZ Gene Knockout Cell Lines involve their ability to model diseases that arise from dysfunctions in oxidative stress response mechanisms. The absence of the CRYZ protein allows for a direct investigation of the downstream effects on cellular metabolism, apoptosis, and signal transduction pathways, facilitating studies on the pathophysiology of conditions such as neurodegeneration and cancer.
The scientific importance of these cell lines lies in their application in both research and clinical settings. They can be utilized to explore therapeutic targets, test drug efficacy, and understand the molecular underpinnings of diseases. Furthermore, CRYZ knockout models serve as a robust platform for gene therapy research and innovative drug development, making them indispensable in translational medicine.
One of the significant advantages of our CRYZ Gene Knockout Cell Lines is the precision with which they have been developed. Compared to alternative models, these cell lines are engineered using advanced CRISPR-Cas9 technology, ensuring a complete and specific knockout with minimal off-target effects. This accuracy translates to reliable experimental outcomes, enhancing the reproducibility of research findings.
For researchers and clinicians alike, the CRYZ Gene Knockout Cell Lines represent a valuable resource that simplifies complex biological inquiries, ultimately contributing to the advancement of scientific knowledge and improved healthcare solutions. Our company prides itself on its expertise in cell line development and genetic engineering, ensuring that our products meet the highest standards of quality and innovation in the field of biological research.
Please note that all services are for research use only. Not intended for any clinical use.
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