Home / CRYZ Knockout Cell Lines

CRYZ Knockout Cell Lines

Gene: CRYZ

Official Full Name: crystallin zetaprovided by HGNC

Gene Summary: Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. The former class is also called phylogenetically-restricted crystallins. This gene encodes a taxon-specific crystallin protein which has NADPH-dependent quinone reductase activity distinct from other known quinone reductases. It lacks alcohol dehydrogenase activity although by similarity it is considered a member of the zinc-containing alcohol dehydrogenase family. Unlike other mammalian species, in humans, lens expression is low. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One pseudogene is known to exist. [provided by RefSeq, Sep 2008]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38402 CRYZ Knockout cell line (HeLa) Human CRYZ 1:3~1:6 Negative Online Inquiry
KO38403 CRYZ Knockout cell line (HCT 116) Human CRYZ 1:2~1:4 Negative Online Inquiry
KO38404 CRYZ Knockout cell line (HEK293) Human CRYZ 1:3~1:6 Negative Online Inquiry
KO38405 CRYZ Knockout cell line (A549) Human CRYZ 1:3~1:4 Negative Online Inquiry

Background

CRYZ Gene Knockout Cell Lines are customized cell lines specifically engineered to provide a complete knockout of the CRYZ gene, which encodes for the enzyme crystallin zeta. This gene is vital in the study of various biological pathways, particularly those associated with oxidative stress and cellular signaling. By creating these knockout lines, researchers are afforded a powerful tool to elucidate the role of CRYZ in health and disease.

Key functional aspects of CRYZ Gene Knockout Cell Lines involve their ability to model diseases that arise from dysfunctions in oxidative stress response mechanisms. The absence of the CRYZ protein allows for a direct investigation of the downstream effects on cellular metabolism, apoptosis, and signal transduction pathways, facilitating studies on the pathophysiology of conditions such as neurodegeneration and cancer.

The scientific importance of these cell lines lies in their application in both research and clinical settings. They can be utilized to explore therapeutic targets, test drug efficacy, and understand the molecular underpinnings of diseases. Furthermore, CRYZ knockout models serve as a robust platform for gene therapy research and innovative drug development, making them indispensable in translational medicine.

One of the significant advantages of our CRYZ Gene Knockout Cell Lines is the precision with which they have been developed. Compared to alternative models, these cell lines are engineered using advanced CRISPR-Cas9 technology, ensuring a complete and specific knockout with minimal off-target effects. This accuracy translates to reliable experimental outcomes, enhancing the reproducibility of research findings.

For researchers and clinicians alike, the CRYZ Gene Knockout Cell Lines represent a valuable resource that simplifies complex biological inquiries, ultimately contributing to the advancement of scientific knowledge and improved healthcare solutions. Our company prides itself on its expertise in cell line development and genetic engineering, ensuring that our products meet the highest standards of quality and innovation in the field of biological research.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.