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CRLF1 Knockout Cell Lines

Gene: CRLF1

Official Full Name: cytokine receptor like factor 1provided by HGNC

Gene Summary: This gene encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. The complex can promote survival of neuronal cells. Mutations in this gene result in Crisponi syndrome and cold-induced sweating syndrome. [provided by RefSeq, Oct 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33398 CRLF1 Knockout cell line (HeLa) Human CRLF1 1:3~1:6 Negative Online Inquiry
KO33399 CRLF1 Knockout cell line (HCT 116) Human CRLF1 1:2~1:4 Negative Online Inquiry
KO33400 CRLF1 Knockout cell line (HEK293) Human CRLF1 1:3~1:6 Negative Online Inquiry
KO33401 CRLF1 Knockout cell line (A549) Human CRLF1 1:3~1:4 Negative Online Inquiry

Background

CRLF1 Gene Knockout Cell Lines are sophisticated biological tools designed for the study of CRLF1 (Cytokine Receptor-Like Factor 1) gene functions and its implications in various physiological and pathological processes. These cell lines have been genetically engineered to eliminate the expression of the CRLF1 gene, thereby providing a model system that allows researchers to dissect the roles of CRLF1 in cellular signaling pathways, immune responses, and potential oncogenic processes.

The key mechanism behind these knockout cell lines lies in the use of CRISPR-Cas9 technology, which enables precise editing of the genome. By knocking out the CRLF1 gene, researchers can observe phenotypic changes and assess how the absence of CRLF1 affects cellular behavior, including proliferation, differentiation, and response to external stimuli. This functionality is crucial for elucidating the gene's role in diseases such as acute lymphoblastic leukemia (ALL) and understanding its contribution to immune dysregulation.

In both research and clinical settings, CRLF1 Gene Knockout Cell Lines hold significant scientific importance. They serve as an indispensable model in drug discovery and therapeutic development, particularly in cancer research, where understanding the role of specific genes can lead to targeted therapies. Additionally, these cell lines facilitate investigations into gene interactions and pathways, fostering breakthroughs in the understanding of complex diseases.

What sets our CRLF1 Gene Knockout Cell Lines apart from alternative models is their high specificity and reliability, as they are rigorously validated for consistent performance and functionality. Their availability allows researchers to bypass the extensive time and resource commitment typically associated with generating knockout models from scratch.

For researchers and clinicians aiming to advance the frontiers of medical science, the CRLF1 Gene Knockout Cell Lines provide an invaluable resource. They not only simplify the experimental process but also enhance the potential for innovative discoveries, ultimately contributing to the development of novel therapeutic approaches.

At [Your Company Name], we are committed to delivering cutting-edge biological research tools, backed by years of expertise in genetic engineering and cell biology. Our products are designed with the utmost quality and reliability, ensuring that our clients can achieve unprecedented insights in their research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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