Gene: CREM
Official Full Name: cAMP responsive element modulatorprovided by HGNC
Gene Summary: This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38429 | CREM Knockout cell line (HeLa) | Human | CREM | 1:3~1:6 | Negative | Online Inquiry |
KO38430 | CREM Knockout cell line (HCT 116) | Human | CREM | 1:2~1:4 | Negative | Online Inquiry |
KO38431 | CREM Knockout cell line (HEK293) | Human | CREM | 1:3~1:6 | Negative | Online Inquiry |
KO38432 | CREM Knockout cell line (A549) | Human | CREM | 1:3~1:4 | Negative | Online Inquiry |
CREM Gene Knockout Cell Lines are genetically engineered cell lines designed for targeted research into the functions of the cAMP response element modulator (CREM) gene. This product is developed through advanced CRISPR/Cas9 technology, ensuring precise disruption of the CREM gene, which plays a critical role in various physiological pathways, including immune response regulation and cell differentiation processes. These cell lines serve as invaluable tools for researchers aiming to elucidate the cellular mechanisms governed by CREM and its implications in diseases such as cancer and neurological disorders.
The key mechanism by which CREM Gene Knockout Cell Lines operate involves the complete ablation of CREM expression, thereby allowing researchers to study the resulting phenotypic and molecular changes. By comparing these knockout cell lines to their wild-type counterparts, scientists can better understand how the absence of CREM affects cellular signaling pathways and gene expression profiles. This functional analysis is crucial in dissecting the pathophysiological roles of CREM and discovering potential therapeutic targets.
In research and clinical settings, these cell lines are essential for investigating CREM's involvement in various biological processes and disease states, opening new avenues for drug development and targeted therapies. Unlike traditional methods of gene knockdown, which may result in partial inhibition and variable results, the complete knockout provides researchers with a robust model to evaluate the true effects of gene loss.
The unique selling points of CREM Gene Knockout Cell Lines include their high specificity, reproducibility, and the ability to be integrated into various high-throughput screening assays. This versatility makes them superior to other methodologies that may not adequately mimic the complete gene loss scenario. Furthermore, these cell lines are validated for consistent performance across multiple experiments, ensuring reliability in experimental outcomes.
For researchers and clinicians, the value of CREM Gene Knockout Cell Lines lies in their potential to advance knowledge in cellular biology and provide insights into therapeutic interventions for CREM-related pathologies. With our expertise in cell line development and genetic engineering, our company is dedicated to offering high-quality products that support innovative research. By equipping scientists with tools like the CREM Gene Knockout Cell Lines, we aim to foster groundbreaking discoveries and advancements in genetic research and biotechnology.
Please note that all services are for research use only. Not intended for any clinical use.
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