Gene: CRB1
Official Full Name: crumbs cell polarity complex component 1provided by HGNC
Gene Summary: This gene encodes a protein which is similar to the Drosophila crumbs protein and localizes to the inner segment of mammalian photoreceptors. In Drosophila crumbs localizes to the stalk of the fly photoreceptor and may be a component of the molecular scaffold that controls proper development of polarity in the eye. Mutations in this gene are associated with a severe form of retinitis pigmentosa, RP12, and with Leber congenital amaurosis. Alternate splicing results in multiple transcript variants, some protein coding and some non-protein coding.[provided by RefSeq, Apr 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO08633 | CRB1 Knockout cell line (HeLa) | Human | CRB1 | 1:3~1:6 | Negative | Online Inquiry |
CRB1 Gene Knockout Cell Lines are specifically engineered cellular models that have had the CRB1 gene inactivated, providing a powerful tool for the study of various biological processes and diseases related to retinal health. The CRB1 gene encodes a crucial protein involved in epithelial cell structure and function, particularly within the retina, highlighting its significance in understanding inherited retinal dystrophies. By systematically silencing this gene, researchers can elucidate its role in disease pathogenesis and validate potential therapeutic targets.
The key mechanism underlying the utility of CRB1 Gene Knockout Cell Lines involves their capacity to model genetic disorders, making them ideal for studying the molecular and cellular mechanisms of CRB1-related pathologies. These cell lines allow for a comparative analysis of cellular responses and signaling pathways in the absence of CRB1, ultimately leading to insights into the mechanisms of retinal degeneration and related disorders. Such models are invaluable for screening drug candidates, assessing gene therapy strategies, and advancing fundamental research programs aimed at understanding retinopathies.
In a clinical and research context, the significance of these cell lines is profound. They provide unparalleled opportunities for investigating disease mechanisms at a cellular level, which can accelerate the drug discovery process by offering a more relevant platform that closely mimics the human condition. Compared to alternative models, such as wild-type cell lines or animal models, CRB1 Gene Knockout Cell Lines are more directly translatable to human disease, allowing for more accurate predictions of therapeutic efficacy.
Researchers, clinicians, and pharmaceutical companies will find immense value in utilizing CRB1 Gene Knockout Cell Lines, as they not only expedite the discovery of novel treatment avenues but also enhance the understanding of retinal diseases. With a commitment to advancing scientific knowledge and improving patient outcomes, our company excels in developing high-quality biological products tailored for cutting-edge research and innovation in the field of genetic and retinal studies.
Please note that all services are for research use only. Not intended for any clinical use.
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