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COX7A2L Knockout Cell Lines

Gene: COX7A2L

Official Full Name: cytochrome c oxidase subunit 7A2 likeprovided by HGNC

Gene Summary: Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen. Several transcript variants, some protein-coding and others non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33506 COX7A2L Knockout cell line (HeLa) Human COX7A2L 1:3~1:6 Negative Online Inquiry
KO33507 COX7A2L Knockout cell line (HCT 116) Human COX7A2L 1:2~1:4 Negative Online Inquiry
KO33508 COX7A2L Knockout cell line (HEK293) Human COX7A2L 1:3~1:6 Negative Online Inquiry
KO33509 COX7A2L Knockout cell line (A549) Human COX7A2L 1:3~1:4 Negative Online Inquiry

Background

COX7A2L Gene Knockout Cell Lines are genetically engineered cell lines specifically designed for the study of the cytochrome c oxidase subunit 7A2-like (COX7A2L) gene's function and its implications in mitochondrial respiration and cellular energy metabolism. These knockout cell lines facilitate the investigation of COX7A2L's role by completely removing the gene's expression, allowing researchers to analyze the downstream effects on metabolic pathways and mitochondrial function.

The primary mechanism of action involves the disruption of the COX7A2L gene, which plays a critical part in the formation and functioning of the cytochrome c oxidase (Complex IV) of the electron transport chain. By utilizing these cell lines, scientists can examine alterations in ATP production, reactive oxygen species (ROS) levels, and overall cellular bioenergetics. This is particularly significant in studies related to metabolic disorders, neurodegenerative diseases, and cancer, where mitochondrial dysfunction is often a central theme.

The scientific importance of COX7A2L Gene Knockout Cell Lines lies in their applications across various research disciplines, including pharmacology, toxicology, and molecular biology. These cell lines serve as a valuable tool for elucidating the physiological roles of COX7A2L and its potential impacts on health and disease, providing critical insights that can lead to novel therapeutic targets.

One of the main advantages of these knockout cell lines is their specificity and reliability in studying gene function, as opposed to using pharmacological inhibitors or other non-specific methods that may yield ambiguous interpretive results. The ability to directly observe the consequences of gene disruption in a controlled setting makes these models superior for precision research endeavors.

This product is invaluable to researchers and clinicians who require robust tools for understanding mitochondrial dynamics and its clinical implications in human health. By providing a clear-cut model for gene function analysis, the COX7A2L Gene Knockout Cell Lines enable targeted research that can streamline the development of therapeutic strategies.

Our company specializes in producing high-quality and validated genetic models, ensuring researchers have access to reliable and innovative tools in their quest for scientific discovery. With our extensive experience in genetic engineering and commitment to excellence, we continually strive to support research endeavors that advance understanding in biology and medicine.

Please note that all services are for research use only. Not intended for any clinical use.

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