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COX7A2 Knockout Cell Lines

Gene: COX7A2

Official Full Name: cytochrome c oxidase subunit 7A2provided by HGNC

Gene Summary: Cytochrome c oxidase, the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of three catalytic subunits encoded by mitochondrial genes, and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, while the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (liver isoform) of subunit VIIa, with this polypeptide being present in both muscle and non-muscle tissues. In addition to polypeptide 2, subunit VIIa includes polypeptide 1 (muscle isoform), which is present only in muscle tissues, and a related protein, which is present in all tissues. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 4 and 14. [provided by RefSeq, Oct 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38467 COX7A2 Knockout cell line (HeLa) Human COX7A2 1:3~1:6 Negative Online Inquiry
KO38468 COX7A2 Knockout cell line (HCT 116) Human COX7A2 1:2~1:4 Negative Online Inquiry
KO38469 COX7A2 Knockout cell line (HEK293) Human COX7A2 1:3~1:6 Negative Online Inquiry
KO38470 COX7A2 Knockout cell line (A549) Human COX7A2 1:3~1:4 Negative Online Inquiry

Background

COX7A2 Gene Knockout Cell Lines are specifically engineered cellular models designed to facilitate the study of the cytochrome c oxidase (COX) complex's function and its role in cellular respiration. This genetic modification involves the targeted disruption of the COX7A2 gene, a critical component of the mitochondrial respiratory chain. By removing this gene, researchers can investigate how alterations in COX activity influence various metabolic pathways, mitochondrial dynamics, and overall cellular health.

The key functions of COX7A2 Gene Knockout Cell Lines revolve around their ability to model respiratory dysfunction and other metabolic disorders. These cell lines allow for the analysis of mitochondrial biogenesis, ATP production, and oxidative stress response mechanisms under controlled experimental conditions. Additionally, they provide insights into diseases linked to mitochondrial dysfunction, including neurodegenerative disorders and certain forms of cancer.

In research and clinical settings, the significance of COX7A2 Gene Knockout Cell Lines is underscored by their ability to serve as essential tools for drug screening and therapeutic development. The distinct profiles of these knockout cell lines facilitate the identification of potential therapeutic agents that may restore normal mitochondrial function or mitigate the effects of mitochondrial-related pathologies.

Compared to conventional cell lines, COX7A2 Gene Knockout Cell Lines offer unique advantages, including improved specificity for studying mitochondrial function without background interference from the normal gene. This specificity allows researchers to obtain clearer, more interpretable data regarding the consequences of COX7A2 deficiency.

For researchers and clinicians focused on the intricacies of mitochondrial biology, these cell lines represent a valuable resource. They not only enhance the understanding of fundamental biological processes but also pave the way for innovative therapeutic strategies targeting mitochondrial dysfunctions.

Our company specializes in advanced genetic engineering technologies, offering a diverse array of biological products that empower researchers in their quest for discoveries in cellular metabolism and disease. With a commitment to quality and innovation, our team remains dedicated to providing researchers with the tools necessary to advance scientific knowledge.

Please note that all services are for research use only. Not intended for any clinical use.

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