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COX6C Knockout Cell Lines

Gene: COX6C

Official Full Name: cytochrome c oxidase subunit 6Cprovided by HGNC

Gene Summary: Cytochrome c oxidase, the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes subunit VIc, which has 77% amino acid sequence identity with mouse subunit VIc. This gene is up-regulated in prostate cancer cells. A pseudogene has been found on chromosomes 16p12. [provided by RefSeq, Jul 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO07346 COX6C Knockout cell line (HeLa) Human COX6C 1:3~1:6 Negative Online Inquiry
KO07347 COX6C Knockout cell line (HCT 116) Human COX6C 1:2~1:4 Negative Online Inquiry
KO07348 COX6C Knockout cell line (HEK293) Human COX6C 1:3~1:6 Negative Online Inquiry

Background

COX6C Gene Knockout Cell Lines are genetically engineered cellular models designed to study the functional role of the cytochrome c oxidase subunit 6C (COX6C) gene in cellular respiration and metabolism. These cell lines have had the COX6C gene selectively disrupted using CRISPR-Cas9 technology, allowing for the investigation of mitochondrial function and energy production pathways. By removing this vital component of the electron transport chain, researchers can observe the physiological and biochemical changes that arise, providing insight into mitochondrial-associated diseases and the mechanisms underlying cellular bioenergetics.

The primary function of COX6C is to facilitate the proper assembly and function of cytochrome c oxidase (complex IV of the mitochondrial respiratory chain), which is crucial for the conversion of molecular oxygen into water and for ATP production. The mechanism of these cell lines allows scientists to elucidate how perturbations in COX6C expression affect overall cellular health, metabolic efficiency, and responses to oxidative stress. By creating a platform for controlled studies on COX6C knockout effects, these cell lines significantly contribute to our understanding of various health conditions, including neurodegenerative diseases, cardiovascular disorders, and metabolic syndromes.

Unlike traditional cell lines, COX6C Gene Knockout Cell Lines offer a targeted approach to studying mitochondrial dysfunction with a specific focus on COX6C’s roles. This level of precision provides researchers with more reliable data, ultimately leading to a better understanding of mitochondrial diseases and potential therapeutic targets. Moreover, these cell lines can be customized for different research needs, allowing scientists in academic and clinical settings to tailor experiments according to their specific hypotheses.

In addition to their scientific importance, COX6C Gene Knockout Cell Lines present unique advantages such as enhanced reproducibility and ease of use in high-throughput screening assays. This practicality makes them indispensable tools for drug discovery and pathophysiological investigations.

With a commitment to advancing scientific knowledge and innovation, our company specializes in the development of cutting-edge biological products, providing researchers and clinicians with the tools necessary to make breakthroughs in their respective fields. The COX6C Gene Knockout Cell Lines exemplify our dedication to creating high-quality, scientifically robust models that empower the pursuit of discovery in mitochondrial biology.

Please note that all services are for research use only. Not intended for any clinical use.

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