Gene: COMMD8
Official Full Name: COMM domain containing 8provided by HGNC
Gene Summary: The protein encoded by this gene binds coiled-coil domain-containing protein 22 (CCDC22), and this complex can regulate the turnover of I-kappa-B and the activation of NF-kappa-B. [provided by RefSeq, Jul 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO18601 | COMMD8 Knockout cell line (HeLa) | Human | COMMD8 | 1:3~1:6 | Negative | Online Inquiry |
KO18602 | COMMD8 Knockout cell line (HCT 116) | Human | COMMD8 | 1:2~1:4 | Negative | Online Inquiry |
KO18603 | COMMD8 Knockout cell line (HEK293) | Human | COMMD8 | 1:3~1:6 | Negative | Online Inquiry |
KO18604 | COMMD8 Knockout cell line (A549) | Human | COMMD8 | 1:3~1:4 | Negative | Online Inquiry |
COMMD8 Gene Knockout Cell Lines are specifically engineered cellular models designed to investigate the function of the COMMD8 gene, which plays a critical role in various biological processes, including copper homeostasis and cellular signaling. These cell lines have been generated using advanced CRISPR-Cas9 technology to create targeted gene disruptions, thereby elucidating the phenotypic consequences of COMMD8 deficiency in a controlled environment.
The primary mechanism of action for these knockout cell lines involves the introduction of double-strand breaks in the COMMD8 gene, followed by the cell’s repair pathways leading to insertions or deletions that disrupt gene function. This allows researchers to study the downstream effects of COMMD8 loss, including any changes in protein interactions, cellular growth, and metabolism. Such models are invaluable for understanding the role of COMMD8 in diseases linked to copper dysregulation and other metabolic disorders.
In terms of scientific significance, COMMD8 Gene Knockout Cell Lines serve as vital tools in both research and clinical applications. They can facilitate the study of basic biological processes, elucidate pathways involved in disease mechanisms, and assist in drug discovery efforts. Researchers can leverage these models to screen for potential therapeutic agents that target COMMD8-related pathways, thus accelerating the translation of findings into clinical applications.
One of the product's standout advantages is the precision and efficiency of the gene editing method employed, ensuring high levels of specificity and reproducibility in experiments. Compared to alternative models, COMMD8 Gene Knockout Cell Lines offer an unparalleled opportunity to study the effects of gene loss without the complications arising from off-target effects commonly associated with older techniques.
For researchers and clinicians aiming to deepen their understanding of copper metabolism and associated pathologies, these cell lines provide a reliable and effective platform. Your ability to generate consistent and meaningful results with our product is enhanced by our dedicated support team, who offers expertise in experimental design and analysis.
Our company prides itself on its commitment to advancing biological research through high-quality products, anchored by extensive experience in cellular model development and gene editing technologies. By choosing COMMD8 Gene Knockout Cell Lines, you are investing in a scientifically robust tool that can propel your research and clinical endeavors to new frontiers.
Please note that all services are for research use only. Not intended for any clinical use.
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