Gene: COL19A1
Official Full Name: collagen type XIX alpha 1 chainprovided by HGNC
Gene Summary: This gene encodes the alpha chain of type XIX collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Although the function of this collagen is not known, other members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve to maintain the integrity of the extracellular matrix. The transcript produced from this gene has an unusually large 3' UTR which has not been completely sequenced. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38489 | COL19A1 Knockout cell line (HEK293) | Human | COL19A1 | 1:3~1:6 | Negative | Online Inquiry |
COL19A1 Gene Knockout Cell Lines represent a sophisticated set of genetically engineered cell models specifically designed to investigate the role of the collagen type XIX alpha 1 (COL19A1) gene in various physiological and pathological processes. Gene knockout techniques involve the targeted disruption of specific genes to elucidate their functional contributions, allowing researchers to assess changes in cellular behavior and complex biological systems.
The principal mechanism underlying these cell lines lies in the complete ablation of the COL19A1 gene, which encodes a protein involved in the structural integrity of the extracellular matrix. By observing the phenotypic alterations and signaling pathway disruptions in these knockout models, researchers can gain insights into the molecular mechanisms driving conditions such as fibrosis, cancer metastasis, and tissue regeneration. This functional analysis is critical as COL19A1 has been increasingly implicated in various diseases, making these models essential for the development of therapeutic strategies.
The scientific importance of COL19A1 Gene Knockout Cell Lines extends beyond basic research; they serve as valuable tools in preclinical studies, drug discovery, and the validation of therapeutic targets. Researchers can leverage these cell lines to test the efficacy of new treatments, understand disease mechanisms, and explore the role of COL19A1 in cellular interactions, thereby accelerating the translation of discoveries from bench to bedside.
A significant advantage of utilizing COL19A1 Gene Knockout Cell Lines over alternative models is the specificity of gene targeting, which permits a more accurate representation of the biological system under investigation. Unlike traditional methods that may rely on pharmacological inhibition, these knockout models allow for a comprehensive assessment of gene function without residual protein effects. Furthermore, our cell lines are rigorously validated to ensure consistent performance and reproducibility, crucial for obtaining reliable experimental results.
This product is indispensable for researchers aiming to uncover the complexities of the extracellular matrix and its role in health and disease. By employing our COL19A1 Gene Knockout Cell Lines, users gain an edge in understanding the nuanced interactions that govern cellular behavior, thereby driving innovation in their respective fields.
Our company is committed to providing high-quality biological products engineered with precision to support groundbreaking research. With expertise in genetic modification and a dedication to scientific integrity, we ensure that our offerings facilitate the advancement of knowledge and the development of transformative therapies.
Please note that all services are for research use only. Not intended for any clinical use.
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