Gene: COL18A1
Official Full Name: collagen type XVIII alpha 1 chainprovided by HGNC
Gene Summary: This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. A long isoform of the protein has an N-terminal domain that is homologous to the extracellular part of frizzled receptors. Proteolytic processing at several endogenous cleavage sites in the C-terminal domain results in production of endostatin, a potent antiangiogenic protein that is able to inhibit angiogenesis and tumor growth. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities, so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO25888 | COL18A1 Knockout cell line (HeLa) | Human | COL18A1 | 1:3~1:6 | Negative | Online Inquiry |
KO25889 | COL18A1 Knockout cell line (HCT 116) | Human | COL18A1 | 1:2~1:4 | Negative | Online Inquiry |
KO25890 | COL18A1 Knockout cell line (HEK293) | Human | COL18A1 | 1:3~1:6 | Negative | Online Inquiry |
KO25891 | COL18A1 Knockout cell line (A549) | Human | COL18A1 | 1:3~1:4 | Negative | Online Inquiry |
COL18A1 Gene Knockout Cell Lines represent a crucial tool in biomedical research, specifically designed to facilitate the study of collagen type XVIII alpha 1 chain, a critical component in various cellular processes, including angiogenesis and tissue remodeling. These cell lines are generated through sophisticated gene-editing techniques, effectively disrupting the COL18A1 gene to model conditions associated with collagen deficiencies or aberrations, such as certain types of cancer and hereditary disorders.
The functionality of these knockout cell lines lies in their ability to provide insights into the role of COL18A1 in cellular behavior, providing a mechanism to evaluate how its absence impacts processes like cell proliferation, migration, and extracellular matrix (ECM) interactions. Researchers can utilize these lines to elucidate the molecular pathways influenced by COL18A1, leading to enhanced understanding and identification of potential therapeutic targets.
In terms of scientific importance, COL18A1 Gene Knockout Cell Lines serve as valuable models for translational research and drug development. They have applications in both basic research, aiding in the discovery of gene functions, and clinical settings, where they can assist in developing targeted therapies. Their use can lead to informed hypotheses regarding the therapeutic potential of modulating COL18A1 expression in pathological conditions.
One of the unique advantages of our COL18A1 Gene Knockout Cell Lines is their reproducibility and high-quality standards, ensuring consistent results across experiments. Compared to alternative models, our cell lines are rigorously validated for effective gene disruption and retained phenotypic characteristics, making them a more reliable choice for researchers looking to explore the implications of COL18A1 in their studies.
The value of these knockout cell lines cannot be understated; they equip researchers and clinicians with the tools necessary to advance our understanding of key biological processes and drive forward innovations in treatment modalities.
With extensive expertise in genomic technologies and a commitment to scientific innovation, our company provides a suite of cutting-edge biological products designed to empower research and enhance therapeutic possibilities.
Please note that all services are for research use only. Not intended for any clinical use.
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